Abstract:

Objective To summarize the latest clinical application characteristics，influencing factors and therapeutic effects of umbilical cord blood（UCB）in Guangdong province，by using the clinical application data from Institution of Guangdong Cord Blood Bank. Methods The clinical application data on 2 132 cord blood samples from Institution of Guangdong Cord Blood Bank from 2007 to 2020 were statistically analyzed，including the types of diseases treated with umbilical cord blood，indexes of cord blood quality，implantation situation after application，and overall survival rate. Results The main disorders treated with UCB from the public banks in Guangdong were blood diseases（87.3%）. There were significant differences in disease type，application area， sex，mononuclear cell number，treatment type and human leukocyte antigen（HLA）⁃matched condition（P < 0.01）. The overall survival rate in the second year was significantly correlated with disease type ，treatment type and implantation status（P < 0.01）. In addition to hematologic diseases，autologous UCB was mostly used in nerve regeneration. Classification of the diseases treated with autologous cord blood was significantly correlated with gender，age，body weight，TNC and frozen blood volume（P < 0.01）. Conclusions The diseases clinically treated with UCB are related to multiple factors such as application area and gender. UCB is mainly used for blood diseas⁃ es，and gradually extended to apply to the treatment of nerve regeneration，showing great potential of cord blood in clinical treatment.

Key words:

cord blood, transplantation, infusion, stem cells