Abstract:

Objective To investigate the clinical effect of PRP（autologous platelet⁃rich plasma）combined with chitosan probe composite on non⁃acute infectious wounds of orthopedic patients. Methods From September 2020 to July 2021，60 patients with non⁃acute infectious wounds on limbs admitted to the orthopedics department of our hospital were randomly divided by digital random method into groups A，B and C treated with chitosan propolis， chitosan PRP and chitosan propolis PRP composite，respectively，20 in each. The scores of pain，anxiety and quality of life after 3，6，9 and 12 days of treatment were evaluated. The wound healing time，healing area and inflammatory indexes before and after treatment were compared and analyzed. Results The scores of pain，anxiety and quality of life in three groups were significantly improved after treatment（P < 0.05）. The healing time of group C was significantly shorter than that of group A and group B（P < 0.05）. After 6 days treatment，the healing area of group C was significantly larger than those of group A and group B（P < 0.05）. After 12 days treatment，the improvement rate of C⁃reactive protein and white blood cell count in group C was significantly higher than those in group A and group B（P < 0.05）. Conclusion PRP combined with chitosan propolis composite material can effectively fight against bacteria，accelerate wound healing，relieve pain and improve the quality of life in orthopedic patients with non⁃acute infectious wounds.

Key words:

chitosan, propolis, PRP, orthopedics, non?acute infection wound