Abstract:

Gastroesophageal reflux disease（GERD）is a common chronic digestive diseases，which is easy to relapse and its pathogenesis is varied，and the spirit of psychological factors often play a key role in them. Psychological factors always play the important role in the pathogenesis and progression of GERD by influencing the mechanisms of esophageal motility and perception，gastric and duodenal motility and central sensory sensitization， and the intervention and treatment of mental factors also achieved good results，in which the selective serotonin reuptake inhibitors（SSRIs）has been recognized for its significant effects. This review summarized the possible mechanism of mental factors in the pathogenesis of GERD and the mechanism and specific application of SSRI in the treatment of GERD，so as to provide clinical reference for the application of SSRI in the clinical treatment of GERD. 

Key words:

selective serotonin reuptake inhibitor, gastroesophageal reflux disease, non?erosive reflux disease, psychosomatic factors