Abstract:

Objective Observing clinical efficacy and the changes in inflammatory response mediatorswith idiopathic pulmonary fibross（IPF）after treating with pulmonary rehabilitation combined with N⁃acetyl cysteine（Nac）and low dose of glucocorticoid. Methods 72 IPF patients were randomly divided into two groups. 36 patientsin conventional therapy group was given symbicort turbuhaler combined with low dose of glucocorticoid and Nac as thebasic treatment. 36 patients in treating group was treated with pulmonary rehabilitation on the basis of conventionaltherapy. The clinical efficacy，the influence on pulmonary function and quality of life，and the inflammatory responsemediators of these two groups were observed. Results The clinic effective rates of conventional therapy group，treating group were 77.8% and 94.4% individually，which had a statistical significance（P < 0.05）. Symptom scor⁃ing，quality of living evaluation，pulmonary function index（FEV1、FVC）and changes of inflammatory factorswere improved in treating group compared with that in conventional therapy group（P < 0.05）. Conclusion IPFpatients treating with pulmonary rehabilitation combined with Nac showed significantly improvement in clinical effi⁃cacy，pulmonary function and quality of life，which also decreasing inflammatory factors expression and restorescorticosteroid responses in IPF.

Key words: low dose of glucocorticoid, N?acetyl cysteine, aerobic anti?obstructive lung rehabilitation therapy, idiopathic pulmonary fibross, inflammatory factors