The Journal of Practical Medicine ›› 2022, Vol. 38 ›› Issue (14): 1838-1846.doi: 10.3969/j.issn.1006⁃5725.2022.14.024

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Role of microglia polarization signaling pathways in neuroinflammation：A literature review

 LI Hongy⁃ing ，SHEN Yuan，WU Qiaofeng，XIE Lushuang，YU Shuguang.   

  1. Acupuncture and Moxibustion College，ChengduUniversity of Traditional Chinese Medicine，Chengdu 610075，China

  • Online:2022-07-25 Published:2022-07-25
  • Contact: XIE Lushuang E⁃mail：xielushuang@cdutcm.edu.cn

Abstract:

Microglia plays a major role in neuroinflammation in brain，for it has a classically activated M1 pro⁃inflammatory phenotype and an alternatively activated anti⁃inflammatory M2 phenotype. Different signaling path⁃ways have been discovered to alter the polarization of microglia and thus exert a regulatory effect on neuroinflamma⁃tion. This article summarizes the feasible pathways in this field to provide new ideas for the follow⁃up research in neuroinflammatory mechanism and therapeutic targets of the inflammation.

Key words: neuroinflammation, microglia, polarization, signaling pathway