Abstract:

Objective To explore the value of Dickkopf⁃1（DKK⁃1）combined with Thromboelastography （TEG）parameters in assessing the risk of recurrence in patients with acute ischemic stroke（AIS）. Methods A total of 293 AIS patients were selected as the research objects. According to the recurrence of AIS patients，they were divided into recurrence group and non ⁃ recurrence group. The general information and TEG parameters of all subjects were collected. The level of serum DKK ⁃1 was detected by enzyme ⁃linked immunosorbent assay kit. The risk factors of recurrence in AIS patients was analyzed，and the evaluation value of the related indexes on the recur⁃ rence of AIS patients was explored. Results The proportion of atrial fibrillation history in the recurrence group was significantly higher than that in the non ⁃ recurrence group（P < 0.05）. The reaction time（RT），and kinetic time（KT）of the recurrence group were shorter and ADP⁃induced platelet⁃fibrin clot strength（MAADP）and DKK⁃1 were higher than those of the non⁃recurrence group（P < 0.05）. The history of atrial fibrillation and the high level of MAADP and DKK⁃1 were the risk factors for the recurrence of AIS（P < 0.05）. DKK⁃1 combined with MAADP was of high value in assessing the risk of recurrence in patients with AIS，and the area under the curve was 0.891 （95%CI：0.843 ~ 0.938）. Conclusion DKK⁃1 and MAADP are closely related to the recurrence of AIS patients， and the combined application of the two is of high value in assessing the risk of recurrence in AIS patients. 

Key words:

acute ischemic stroke, Dickkopf?1, thromboelastography, ADP?induced platelet?fibrin clot strength, recurrence