The Journal of Practical Medicine ›› 2022, Vol. 38 ›› Issue (7): 795-798.doi: 10.3969/j.issn.1006⁃5725.2022.07.004

• Special Report • Previous Articles     Next Articles

Research progress of sepsis⁃related liver injury and gut⁃liver axis

ZHANG Jie*，LI Xiaoyue，HUANG Jiahua， HAN Jing.   

  1. Department of Critical Care Medicine and Emergency，Department of the Fifth Affiliated Hospital of Zunyi Medical University（Zhuhai），Zhuhai 519100，China 

  • Online:2022-04-10 Published:2022-04-10
  • Contact: LI Xiaoyue E⁃mail：euyeuy1983@126.com

Abstract:

Sepsis is one of the most common causes of death in critically ill patients. Sepsis⁃related liver injury is a common complication of sepsis，which is related to microcirculation dysfunction，oxygen free radical injury，intestinal bacterial and endotoxin translocation，and excessive production of inflammatory factors. It is believed that the gut ⁃liver axis is involved in the development of sepsis ⁃ related liver injury. Further study on the role of gut⁃liver axis in the pathogenesis of sepsis⁃related liver injury will help to find more effective treatment mea⁃ sures and improve the success rate of rescue in sepsis patients.

Key words:

sepsis?related liver injury, gut?liver axis, gut flora