Abstract:

Objective To observe the effect of Shanzha Xiaozhi Capslue on essential hypertension with carotid arteriosclerosis（the stasis⁃phlegm combined pattern from the perspective of TCM）. Methods According to the inclusion criteria，a total of 79 patients with essential hypertension combined with carotid atherosclerosis were randomly assigned to treatment group（n = 39）and control group（n = 40）. All patients received routine treatment and those in the treatment group were additionally given Shanzha Xiaozhi Capslue for 6 months. The change of TCM pattern，the change of carotid intima media thickness（IMT），brachial⁃ankle pulse wave velocity（baPWV），ankle ⁃brachial index（ABI），homocysteine（HCY），lipoprotein associated phospholipase A2（Lp⁃PLA2）and safety were observed. Results After treatment，the total effective rate for TCM pattern was 87.18% in the treatment group and 67.50% in the control group（P < 0.05）；The levels of baPWV，ABI and HCY in the two groups were significantly improved（P < 0.01），and those in the treatment group were significantly improved（P < 0.01）. The levels of LMT and Lp⁃PLA2 were not significantly improved in the control group（P > 0.05），but were significantly improved in the treatment group（P < 0.01），which was better than the control group（P < 0.05）. In terms of safety，there were no significant abnormalities in liver function，renal function，or creatine kinase in the two groups. Conclusion Shanzha Xiaozhi Capslue was effective and safe for essential hypertension combined with carotid arteriosclerosis.

Key words:

Shanzha Xiaozhi Capslue, stasis ? phlegm combined pattern, hypertension, carotid arteriosclerosis, clinical study