The Journal of Practical Medicine ›› 2021, Vol. 37 ›› Issue (7): 948-952.doi: 10.3969/j.issn.1006⁃5725.2021.07.024

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Role of circulating tumor DNA in diagnosis and treatment of pancreatic cancer：A literature review

JIA Yanhui*，DU Shuangshuang，LIU Shuye   

  1. Clinical Laboratory of Tianjin Third Central Hospital，Tianjin 300170， China；*Tianjin Key Laboratory of Artificial Cells，Tianjin 300170，China；*Artificial Cell Engineering Technology Research Center of Ministry of Health，Tianjin 300170，China

  • Online:2021-04-10 Published:2021-04-10
  • Contact: LIU Shuye E⁃mail：liushuye@tijmu.edu.cn

Abstract:

Pancreatic cancer is a lethal malignancy with poor prognosis，and it is a serious threat to human health. Imaging examination，serum carbohydrate antigen 19⁃9（CA19⁃9）and tissue biopsy have some limitations in the diagnosis and treatment of pancreatic cancer.Circulating tumor DNA（ctDNA）is one of the newly emerging technologies for“liquid biopsy”. It has shown promising clinical application in the precise treatment of pancreatic cancer due to its simple ，non⁃invasive sampling and real⁃time monitoring of cancer burden. In the study ，we reviewed the application of ctDNA in the early diagnosis of pancreatic cancer，disease stratification，prediction of postoperative recurrence，longitudinal monitoring of treatment response，hoping to provide some references for scientific research and clinical practice.

Key words:

pancreatic cancer, liquid biopsies, circulating tumor DNA, precision medicine