Abstract:

Objective To explore the effect of Helicobacter pylori（Hp）infection on pregnancy outcome in patients with GDM. Methods A total of 179 pregnant women having regular prenatal examinations in our hospital were randomly selected，then divided into GDM group（66 cases）and control group（113 cases）according to the screening results of OGTT. All pregnant women were tested for Hp serum antibodies by fasting venous blood in the next morning. The Hp infection rate of the two groups of patients was compared. GDM group was sub⁃divided into Hp positive group and Hp negative group. The pregnancy outcome of the Hp positive group and Hp negative group was compared. Results （1）Hp infection rate in GDM group was 57.57%，which was apparently higher than that in the control group of 33.62%（P = 0.002）.（2）In patients with GDM，gestational week of delivery，fetal head and abdominal circumference in pregnancy end，newborn weight and body length of Hp positive group were notably shorter or lower than these in Hp negative group（P＜0.05）. Incidence of hyperemesis gravidarum（HG），pre⁃ eclampsia（PE），preterm birth and abortion in Hp positive group was significantly higher than that in Hp negative group（P＜0.05）. Conclusion Hp infection is prevalent in GDM patients，and GDM patients are more susceptible to Hp infection than normal pregnant women，which affects the pregnancy outcome of GDM patients.

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