Abstract:

Objective Based on the success in preparation of vancomycin⁃incorporated PLGA/TCP scaf⁃ fold，its effect of repair infected femur defects in goats was evaluated. Methods A goat model of infected femur defects was established and the goats were randomly assigned to three groups. The experimental group 1 was implanted with vancomycin⁃incorporated PLGA/TCP scaffold，the control group 1 was implanted with antibiotic⁃PMMA（poly⁃ methyl methacrylate）and the control group 2 was served as a blank control group. White blood cells（WBC），erythro⁃ cyte sedimentation rate（ESR）and C⁃reactive protein（CRP）were detected at different time points. The content and antibacterial activity of vancomycin were detected in local tissues. X ⁃ ray and hematoxylin ⁃eosin（HE）stain were performed to assess biodegradation of the scaffold and bone reconstruction. Results All of the animals survived. The experimental group 1 and the control group 1 had better anti ⁃infective effect. As compared with the blank control group，ESR and CRP were significantly lower in the other two groups at weeks 4，8 and 12 after operation（P < 0.05）. Besides，the experimental group 1 showed more biodegradation and bone reconstruction than the control group （P < 0.05）. As compared with the control group，the degree of inflammatory reaction was less in the experimental group 1 and the control group 1. Conclusions The composite vancomycin⁃incorporated PLGA/TCP porous scaffold can not only be added anti⁃infective drugs，but also customize implant materials according to the shape of femur defects. The efficacy of anti⁃infection is hopefully achieved，

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