The Journal of Practical Medicine ›› 2026, Vol. 42 ›› Issue (18): 3278-3288.doi: 10.3969/j.issn.1006-5725.2026.18.006
• Chronic Disease Control • Previous Articles
Received:2026-06-01
Revised:2026-07-23
Accepted:2026-07-24
Online:2026-09-25
Published:2026-10-19
Contact:
Ying Zhang
About author:Kang Ning designed the study, developed the study model, performed the statistical analyses, and prepared the manuscript. Zhang Ying provided expert guidance throughout the study design and implementation, contributed to manuscript writing and revision, conceived the study, and supervised the overall study. All authors read and approved the final manuscript as submitted.
CLC Number:
Ning Kang, Ying Zhang. Association between metabolic score for visceral fat and heart failure in individuals with diabetes or prediabetes: NHANES 1999-2018[J]. The Journal of Practical Medicine, 2026, 42(18): 3278-3288.
Tab.1
Characteristics of participants"
| 特征 | n* | 总体 (n = 1 085 505 572) | Q1 (n = 271 350 392) | Q2 (n = 271 374 692) | Q3 (n = 271 395 482) | Q4 (n = 271 385 002) | P值# |
|---|---|---|---|---|---|---|---|
| METS-VF | 12 090 | 6.99(6.61,7.29) | 6.23(5.86,6.44) | 6.81(6.72,6.91) | 7.13(7.06,7.21) | 7.47(7.37,7.60) | < 0.001 |
| 年龄/岁 | 12 090 | 53(40,65) | 42(30,55) | 50(39,62) | 55(45,66) | 61(51,69) | < 0.001 |
| 性别/[例(%)] | 12 090 | < 0.001 | |||||
| 男 | 6 562(55) | 1 341(51) | 1 406(49) | 1 590(52) | 2 225(68) | ||
| 女 | 5 528(45) | 1 366(49) | 1 533(51) | 1 595(48) | 1 034(32) | ||
| 种族/[例(%)] | 12 090 | < 0.001 | |||||
| 墨西哥裔美国人 | 2 258(8.9) | 404(8.3) | 608(11) | 643(9.3) | 603(7.1) | ||
| 其他西班牙裔 | 1 116(5.5) | 233(5.7) | 273(6.4) | 312(5.7) | 298(4.4) | ||
| 非西班牙裔白人 | 5 132(67) | 1 025(62) | 1 141(63) | 1 342(68) | 1 624(75) | ||
| 非西班牙裔黑人 | 2 416(11) | 560(12) | 594(12) | 659(12) | 603(9.7) | ||
| 其他种族 | 1 168(7.4) | 485(12) | 323(8.5) | 229(5.1) | 131(4.1) | ||
| 家庭PIR/[例(%)] | 12 090 | 0.146 | |||||
| PIR < 1.3 | 3 741(22) | 843(23) | 868(21) | 1,032(23) | 998(20) | ||
| 1.3 ≤ PIR < 3.5 | 4 838(38) | 1 032(37) | 1 177(39) | 1 254(37) | 1 375(41) | ||
| PIR ≥ 3.5 | 3 511(40) | 832(40) | 894(40) | 899(40) | 886(39) | ||
| 教育水平/[例(%)] | 12 090 | < 0.001 | |||||
| 高中以下学历 | 3 607(20) | 638(17) | 856(21) | 1 044(22) | 1 069(20) | ||
| 高中学历 | 2 871(26) | 635(24) | 708(25) | 754(26) | 774(27) | ||
| 高中以上学历 | 5,612(54) | 1,434(59) | 1,375(54) | 1,387(52) | 1,416(53) | ||
| 婚姻状况/[例(%)] | 12 090 | < 0.001 | |||||
| 已婚或处于伴侣关系 | 7 647(67) | 1 601(62) | 1 907(69) | 2 039(67) | 2 100(68) | ||
| 单身 | 1 449(12) | 561(21) | 332(11) | 296(9.4) | 260(8.8) | ||
| 曾有伴侣关系 | 2 994(21) | 545(17) | 700(20) | 850(23) | 899(23) | ||
| BMI/(kg/m2) | 12 090 | 29(26,34) | 24(22,26) | 28(26,30) | 31(28,34) | 36(32,41) | < 0.001 |
| 体质量/kg | 12 090 | 85(72,99) | 69(61,79) | 79(71,89) | 89(79,100) | 106(93,121) | < 0.001 |
| 腰围/cm | 12 090 | 102(93,113) | 87(81,92) | 98(94,103) | 107(102,112) | 120(113,130) | < 0.001 |
| 吸烟/[例(%)] | 12 090 | < 0.001 | |||||
| 不吸烟 | 6 185(50) | 1 487(53) | 1 651(54) | 1 643(49) | 1 404(44) | ||
| 既往吸烟 | 3 524(30) | 517(21) | 706(26) | 926(31) | 1 375(41) | ||
| 当前吸烟 | 2 381(20) | 703(26) | 582(20) | 616(20) | 480(15) | ||
| 饮酒/[例(%)] | 12 090 | < 0.001 | |||||
| 不饮酒 | 3 167(22) | 636(20) | 784(23) | 911(24) | 836(23) | ||
| 轻至中度饮酒 | 1 195(10) | 231(9.0) | 261(9.2) | 294(9.6) | 409(13) | ||
| 重度饮酒 | 5 390(51) | 1 416(58) | 1 396(54) | 1 358(49) | 1 220(43) | ||
| 缺失数据 | 2 338(16) | 424(13) | 498(15) | 622(17) | 794(21) | ||
| 能量摄入/kcal | 12 090 | 2 021(1 487,2 677) | 2 061(1 545,2 763) | 1 964(1 453,2 621) | 2 006(1 456,2 629) | 2 072(1 512,2 729) | 0.01 |
| 收缩压/mmHg | 12 090 | 123(114,135) | 117(109,128) | 123(113,134) | 125(117,137) | 128(118,141) | < 0.001 |
| 舒张压/mmHg | 12 090 | 71(64,79) | 70(63,76) | 72(65,79) | 73(65,80) | 72(64,79) | < 0.001 |
| HbA1c/% | 12 090 | 5.70(5.40,6.00) | 5.50(5.20,5.70) | 5.60(5.30,5.90) | 5.70(5.40,6.10) | 5.90(5.60,6.60) | < 0.001 |
| FBG/mmol/L | 12 090 | 5.94(5.66,6.49) | 5.72(5.55,6.00) | 5.83(5.61,6.22) | 6.00(5.69,6.61) | 6.33(5.83,7.38) | < 0.001 |
| 胰岛素/uU/mL | 12 090 | 12(7,18) | 7(5,11) | 10(7,15) | 13(9,19) | 18(12,28) | < 0.001 |
| TC/mmol/L | 12 090 | 5.02(4.34,5.77) | 4.97(4.29,5.72) | 5.20(4.53,5.92) | 5.09(4.45,5.82) | 4.84(4.16,5.59) | < 0.001 |
| 甘油三酯/mmol/L | 12 090 | 1.33(0.93,1.96) | 1.02(0.72,1.41) | 1.31(0.93,1.96) | 1.46(1.02,2.08) | 1.64(1.17,2.29) | < 0.001 |
| LDL-C/mg/dL | 12 090 | 115(92,140) | 112(92,138) | 120(97,144) | 118(95,142) | 109(85,134) | < 0.001 |
| 肌酐/umol/L | 12 090 | 76(64,88) | 72(62,86) | 73(62,88) | 77(64,88) | 80(70,94) | < 0.001 |
| 自报CHD/[例(%)] | 12 090 | 676(5.1) | 55(2.1) | 103(3.0) | 178(4.9) | 340(10) | < 0.001 |
| 自报心绞痛/[例(%)] | 12 090 | 444(3.4) | 36(1.5) | 65(2.0) | 132(3.8) | 211(6.3) | < 0.001 |
| 自报心肌梗死/[例(%)] | 12 090 | 700(5.0) | 58(2.1) | 121(3.7) | 178(4.9) | 343(9.5) | < 0.001 |
| 自报卒中/[例(%)] | 12 090 | 540(3.7) | 46(1.5) | 98(2.5) | 148(4.4) | 248(6.3) | < 0.001 |
| 自报癌症或恶性肿瘤/[例(%)] | 12 090 | 1 377(12) | 207(8.2) | 273(9.4) | 360(12) | 537(17) | < 0.001 |
| 自报高血压/[例(%)] | 12 090 | 5 653(51) | 1 916(74) | 1 573(58) | 1 269(42) | 895(30) | < 0.001 |
| 自报高脂血症/[例(%)] | 12 090 | 5 663(45) | 839(30) | 1 281(42) | 1 678(51) | 1 865(58) | < 0.001 |
| 心源性死亡/[例(%)] | 10 511 | 572(4.1) | 54(1.8) | 104(2.8) | 147(4.1) | 267(8.0) | < 0.001 |
| 糖尿病相关死亡/[例(%)] | 10 248 | 309(2.2) | 29(0.9) | 55(1.5) | 72(1.9) | 153(4.9) | < 0.001 |
Tab.2
Association between METS-VF and heart failure"
| 项目 | 模型1 | 模型2 | 模型3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95%CI | P值 | OR | 95%CI | P值 | OR | 95%CI | P值 | |
| METS-VF | 5.233 | 3.501 ~ 7.822 | < 0.001 | 3.08 | 1.968 ~ 4.820 | < 0.001 | 2.751 | 1.757 ~ 4.308 | < 0.001 |
| 类别 | |||||||||
| Q1(< 6.606) | 1(参照组) | 1(参照组) | 1(参照组) | 1(参照组) | 1(参照组) | 1(参照组) | |||
| Q2(6.606 ~ 6.988) | 1.434 | 0.755 ~ 2.724 | 0.268 | 0.995 | 0.527 ~1.879 | 0.987 | 1.071 | 0.569 ~ 2.017 | 0.83 |
| Q3(6.988 ~ 7.291) | 2.434 | 1.313 ~ 4.512 | 0.005 | 1.311 | 0.706 ~ 2.437 | 0.389 | 1.446 | 0.797 ~ 2.624 | 0.223 |
| Q4(≥ 7.291) | 6.505 | 3.649 ~ 11.60 | < 0.001 | 3.036 | 1.697 ~ 5.434 | < 0.001 | 2.998 | 1.645 ~ 5.465 | < 0.001 |
| 趋势性检验 P值 | < 0.001 | < 0.001 | < 0.001 | ||||||
Tab.3
Analysis of the threshold effect of METS-VF on heart failure using a two-piecewise logistic regression model"
| 阈值效应分析 | HF | P值 |
|---|---|---|
| OR(95%CI) | ||
| METS⁃VF(模型1) | ||
| METS⁃VF拐点(模型1)(K) | 7.024 | |
| K左侧斜率 | 2.230(1.324 ~ 3.758) | 0.003 |
| K右侧斜率 | 10.22(6.729 ~ 15.53 ) | < 0.001 |
| 对数似然比检验 | < 0.001 | |
| METS⁃VF(模型3) | ||
| METS⁃VF拐点(模型3)(K) | 7.024 | |
| K左侧斜率 | 1.405(0.842 ~ 2.343) | 0.191 |
| K右侧斜率 | 5.552(3.043 ~ 10.13) | < 0.001 |
| 对数似然比检验 | 0.001 | |
| METS⁃VF(男性,模型1) | ||
| METS⁃VF拐点(模型1,男性)(K) | 7.024 | |
| K左侧斜率 | 3.628(1.633 ~ 8.062) | 0.002 |
| K右侧斜率 | 10.14(5.985 ~ 17.17) | < 0.001 |
| 对数似然比检验 | 0.085 | |
| METS⁃VF(男性,模型3) | ||
| METS⁃VF拐点(模型3,男性)(K) | 7.024 | |
| K左侧斜率 | 1.801(0.824 ~ 3.937) | 0.139 |
| K右侧斜率 | 4.451(1.954 ~ 10.14) | < 0.001 |
| 对数似然比检验 | 0.146 | |
| METS⁃VF(女性,模型1) | ||
| METS⁃VF拐点(模型1,女性)(K) | 7.024 | |
| K左侧斜率 | 1.461(0.751 ~ 2.841) | 0.262 |
| K右侧斜率 | 21.59(8.780 ~ 53.10) | < 0.001 |
| 对数似然比检验 | < 0.001 | |
| METS⁃VF(女性,模型3) | ||
| METS⁃VF拐点(模型3,女性)(K) | 7.024 | |
| K左侧斜率 | 1.089(0.556 ~ 2.131) | 0.802 |
| K右侧斜率 | 9.635(3.180 ~ 29.19) | < 0.001 |
| 对数似然比检验 | 0.001 |
Tab.4
Subgroup analyses for the association between METS-VF and heart failure"
| 项目 | HF事件数/样本量 | METS-VF | 交互作用 P值 | ||
|---|---|---|---|---|---|
| OR | 95%CI | P值 | |||
| 性别 | 0.904 | ||||
| 男 | 284/6 562 | 3.094 | 1.834 ~ 5.217 | < 0.001 | |
| 女 | 220/5 528 | 2.411 | 1.251 ~ 4.647 | 0.009 | |
| 种族 | 0.361 | ||||
| 非西班牙裔白人 | 265/5 132 | 2.277 | 1.381 ~ 3.756 | 0.002 | |
| 非西班牙裔黑人 | 116/2 416 | 2.771 | 1.460 ~ 5.259 | 0.002 | |
| 其他种族 | 123/4 542 | 6.466 | 2.051 ~ 20.385 | 0.002 | |
| 教育水平 | 0.985 | ||||
| 高中以下学历 | 209/3 607 | 3.291 | 1.888 ~ 5.738 | < 0.001 | |
| 高中学历 | 117/2 871 | 3.099 | 1.362 ~ 7.048 | 0.007 | |
| 高中以上学历 | 178/5 612 | 2.566 | 1.127 ~ 5.839 | 0.025 | |
| 家庭PIR | 0.974 | ||||
| PIR < 1.3 | 194/3 741 | 3.277 | 1.750 ~ 6.138 | < 0.001 | |
| 1.3 ≤PIR <3.5 | 224/4 838 | 2.339 | 1.350 ~ 4.050 | 0.003 | |
| PIR ≥ 3.5 | 86/3 511 | 3.285 | 0.961 ~ 11.23 | 0.058 | |
| 吸烟 | 0.632 | ||||
| 不吸烟 | 209/6 185 | 2.594 | 1.348 ~ 4.991 | 0.005 | |
| 既往吸烟 | 197/3 524 | 3.55 | 1.976 ~ 6.380 | < 0.001 | |
| 当 前吸烟 | 98/2 381 | 2.782 | 1.184 ~ 6.539 | 0.019 | |
| 自报癌症或恶性肿瘤 | 0.029 | ||||
| 是 | 116/1 377 | 1.648 | 0.936 ~ 2.904 | 0.083 | |
| 否 | 388/10 713 | 3.289 | 1.875 ~ 5.768 | < 0.001 | |
| 自报CHD | 0.189 | ||||
| 是 | 199/676 | 1.962 | 1.119 ~ 3.439 | 0.019 | |
| 否 | 305/11 414 | 3.186 | 1.847 ~ 5.496 | < 0.001 | |
| 自报心肌梗死 | 0.033 | ||||
| 是 | 224/700 | 1.556 | 0.849 ~ 2.853 | 0.151 | |
| 否 | 280/11 390 | 3.48 | 2.044 ~ 5.926 | < 0.001 | |
Tab.5
ROC analysis and identification performance of METS-VF, METS-IR, and WHtR for identifying heart failure"
| 指标 | AUC(95%CI) | 最佳截断值 | 灵敏度/% | 特异度/% | 约登指数 |
|---|---|---|---|---|---|
| METS-VF | 0.701(0.677 ~ 0.724) | 7.207 | 64.3 | 67.1 | 0.314 |
| METS-IR | 0.600(0.574 ~ 0.625) | 49.685 | 48.6 | 67.2 | 0.158 |
| WHtR | 0.630(0.606 ~ 0.655) | 0.627 | 61.5 | 59.2 | 0.207 |
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