阿尔茨海默病中DNA甲基化与氧化应激的双向调控与正反馈网络

doi:10.3969/j.issn.1006-5725.2025.24.002

Abstract

Abstract:

Alzheimer's disease （AD） is a neurodegenerative disorder characterized by β-amyloid （Aβ） deposition and hyperphosphorylation of the Tau protein. Oxidative stress plays a pivotal role throughout its pathological progression. Recent studies have demonstrated that DNA methylation， a key epigenetic regulatory mechanism， interacts with oxidative stress to form a core network underlying AD pathogenesis. This review summarizes the molecular mechanisms through which aberrant DNA methylation in AD exacerbates oxidative damage by impairing antioxidant defenses， inducing mitochondrial dysfunction， and activating inflammatory pathways. Moreover， it examines the bidirectional interplay between oxidative stress and DNA methylation imbalance in AD： Oxidative stress depletes methyl donors， causes oxidative DNA lesions， and impairs the activity of epigenetic regulatory enzymes. The study aims to identify potential molecular diagnostic markers for early-stage AD and to provide novel insights and a theoretical basis for developing combined therapeutic strategies targeting both redox imbalance and epigenetic dysregulation.

Key words: Alzheimer's disease, DNA methylation, oxidative stress, Aβ deposition, Tau protein, mitochondrion

CLC Number:

R741

Zhiyi CHEN,Sirui LIU,Jingxian HAN,Xuezhu. ZHANG. Interaction between DNA methylation and oxidative stress in Alzheimer′s disease： Bidirectional regulation and positive⁃feedback networks[J]. The Journal of Practical Medicine, 2025, 41(24): 3802-3808.

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Interaction between DNA methylation and oxidative stress in Alzheimer′s disease： Bidirectional regulation and positive⁃feedback networks

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