针刺会阴穴联合清毒洗液治疗高危型人乳头瘤病毒持续感染的疗效

doi:10.3969/j.issn.1006-5725.2025.16.013

Abstract

Abstract:

Objective To retrospectively assess the clinical efficacy of acupuncture at the Huiyin point combined with Qingdu wash solution in the treatment of high-risk HPV infection. Methods A total of 264 patients who were initially diagnosed with high-risk HPV infection at the University City Gynecology Department of Guangdong Provincial Hospital of Traditional Chinese Medicine between January 2022 and June 2024 were enrolled in the study. These patients were divided into two groups based on predefined inclusion and exclusion criteria. The observation group included 134 patients who received acupuncture at the Huiyin acupoint combined with Qingdu wash solution， while the control group consisted of 130 patients who did not receive any intervention. The treatment period lasted for three months， during which the short-term clinical efficacy and safety profile were evaluated. Results The HR-HPV clearance rates in the observation group at 3 months and 6 months were 61.9% and 65.7%， respectively， which were significantly higher than those in the control group （16.9% and 21.5%）， and the differences between the two groups were statistically significant （P < 0.001）. Following a three-month treatment regimen， the rate of HR-HPV positive-to-negative conversion in the observation group was significantly higher than that in the control group， with a statistically significant intergroup difference （P < 0.001）. The improvement in traditional Chinese medicine （TCM）-related symptoms was also significantly better in the observation group compared to the control group （P < 0.05）. During the follow-up period， no cases of recurrence were observed in the observation group， whereas the recurrence rate in the control group was 1.5%. Furthermore， no adverse reactions were reported in the observation group throughout the treatment period. Conclusion Acupuncture at the Huiyin point， when combined with Qingdu wash solution， can enhance the therapeutic outcomes of high-risk HPV infection and demonstrates a favorable safety profile.

Key words: infection of high-risk human papilloma virus（HR-HPV）, Huiyin point, Qingdu Lotion, curative effect

CLC Number:

R711

Tingting DU,Jing XIAO,Jingyan ZHU,Xiaofeng CHEN,Lingjuan HU,Liner CAI,Meiling YAO,Hong. TANG. Efficacy of acupuncture at Huiyin combined with Qingdu Lotion in the treatment of high-risk human papillomavirus （HPV） persistent infection[J]. The Journal of Practical Medicine, 2025, 41(16): 2528-2532.

Figures/Tables 9

Tab.1

Comparison of baseline data between the two groups of patients"

组别	例数	年龄（ $x ˉ$ ± s）/岁	病程（ $x ˉ$ ± s）/月	孕次	产次	流产次数
观察组	134	39.68 ± 9.07	15.04 ± 4.00	2.0（1.0，2.0）	1.0（1.0，2.0）	0.5（0，1.0）
对照组	130	41.04 ± 9.03	14.37 ± 3.86	2.0（1.0，2.0）	1.0（1.0，2.0）	0.5（0，1.0）
t/Z值		1.220	1.397	1.306	1.039	0.680
P值		0.988	0.776	0.193	0.299	0.496

Tab.1

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References 18

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组别	样本量	治疗前
观察组	134	16.22 ± 2.10
对照组	130	16.67 ± 2.01
t值		-1.792
P值		0.074

组别	样本量	治疗前	纳入后第6个月	Z值	P值
观察组	134	16.00（15.00，18.00）	1.00（0.00，2.00）	-10.063	< 0.001
对照组	130	17.00（15.00，18.00）	12.00（11.00，15.00）	-8.825	< 0.001

组别	样本量	治疗前	纳入后第9个月	Z值	P值
观察组	134	16.00（15.00，18.00）	1.00（0.00，2.25）	-10.061	< 0.001
对照组	130	17.00（15.00，18.00）	10.00（9.00，12.00）	-9.477	< 0.001

组别	样本量	纳入后第6个月	纳入后第9个月	Z值	P值
观察组	134	1.00（0.00，2.25）	1.00（0.00，2.00）	5.652	< 0.001
对照组	130	10.00（9.00，12.00）	12.00（11.00，15.00）	-6.757	< 0.001

	第6个月
组别	痊愈	显效	有效	无效	有效率/%	Z值	P值
观察组	63	70	1	0	100.0	-13.871	< 0.001
对照组	0	11	43	76	41.5	-13.871	< 0.001

Efficacy of acupuncture at Huiyin combined with Qingdu Lotion in the treatment of high-risk human papillomavirus （HPV） persistent infection

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组别	样本量	转阴	有效	维持	进展	Z值	P值
观察组	134	83	28	23	0	- 9.337	< 0.001
对照组	130	22	15	53	40	- 9.337	< 0.001

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