Endo-LOVE联合内镜下神经根射频脉冲治疗腰椎退行性疾病临床疗效

doi:10.3969/j.issn.1006-5725.2025.12.005

Abstract

Abstract:

Objective To explore the clinical effectiveness of full endoscopic lamina fenestration discectomy （Endo-LOVE） in combination with nerve root pulsed radiofrequency （NR-PRF） in the treatment of lumbar degenerative disease （LDD）， along with the amelioration of postoperative residual symptoms. Methods A retrospective analysis was performed on 102 patients with LDD who were treated in our hospital between January 2022 and June 2023. Among them， 53 cases were assigned to the observation group （receiving Endo-LOVE combined with NR-PRF）， and 49 cases were included in the control group （undergoing Endo-LOVE alone）. The mean follow-up period was 15.05 ± 1.15 months. The general data of the two groups were compared. Observations were carried out at preoperative， 1-day， 7-day， 1-month， 3-month， 6-month， and final follow-up time points postoperatively. The perioperative data and follow-up outcomes of the two groups were compared. Results Prior to surgery， no significant disparities were detected in the general conditions and clinical observation indicators （VAS， M-JOA， and ODI scores） between the two groups. Postoperatively， both groups exhibited a notable improvement in clinical indicators when compared to the preoperative levels （P < 0.05）. Within three months after surgery， the observation group showed significantly more pronounced improvement in all clinical indicators than the control group （P < 0.05）. At six months postoperatively and during the final follow-up， no statistically significant differences in clinical indicators were found between the two groups. Moreover， at the final follow-up， there was no statistically significant difference in the Macnab scores between the two groups （P > 0.05）. Conclusion Endoscopic decompression for the treatment of LDD exhibits high safety and reliability. When combined with endoscopic NR-PRF， it enhances the clinical efficacy， reduces the incidence of postoperative residual symptoms， and facilitates rapid postoperative recovery. This complementary combination presents a novel therapeutic strategy for LDD.

Key words: lumbar degenerative disease, endoscopic decompression, nerve root pulsed radiofrequency, combination therapy, clinical efficacy

CLC Number:

R274.9

Rouzi REBOTE,Hanshuo ZHANG,Guangnan YANG,Jie BAI,Qiang JIANG,Zhengcao LU,Wen LI,Yu DING. Clinical observation of Endo⁃LOVE combined with NR⁃PRF in the treatment of LDD：Focusing on the improvement of postoperative residual symptoms[J]. The Journal of Practical Medicine, 2025, 41(12): 1800-1807.

Figures/Tables 5

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References 30

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项目	观察组（n = 53）Endo-LOVE+NR-PRF	对照组（n = 49）Endo-LOVE	t/χ² 值	P值
性别（男/女）/例	32/21	29/20	1.28	0.902
年龄/岁	55.6 ± 10.4	53.4 ± 9.7	1.31	0.189
体质量指数/（kg/m²）	21.9 ± 2.1	21.9 ± 2.1	0.44	0.189
病程/月	12.4 ± 2.2	12.9 ± 1.9	1.22	0.224
随访时间/月	15.2 ± 1.2	14.9 ± 1.1	1.31	0.192
手术节段/例	53	49	0.51	0.475
L_4/5	35	29
L₅/S₁	18	20
疾病类型（例）	53	49	0.48	0.490
腰椎间盘突出症	39	33
腰椎管狭窄症	14	16

指标	观察组（n = 53）	对照组（n = 49）	t/χ²量	P值
VAS分值/分
治疗前	7.21 ± 1.17	7.24 ± 1.30	0.12	0.903
术后1 d	2.74 ± 1.04^?	3.73 ± 1.13^?	4.15	< 0.001^#
术后1周	2.45 ± 1.01^?	3.12 ± 1.18^?	2.55	0.011^#
术后1月	2.08 ± 0.83^?	2.51 ± 0.94^?	2.25	0.025^#
术后3月	1.36 ± 0.76^?	1.76 ± 0.78^?	2.54	0.011^#
术后6月	1.08 ± 0.62^?	1.18 ± 0.73^?	0.78	0.434
末次随访（≥ 12月）	0.81 ± 0.52^?	0.88 ± 0.67^?	0.43	0.667
M?JOA分值/分
治疗前	12.09 ± 1.47	12.33 ± 1.59	0.74	0.457
术后1周	14.12 ± 1.97^?	13.24 ± 1.49^?	2.44	0.015^#
术后1月	15.06 ± 1.59^?	14.31 ± 1.25^?	2.50	0.012^#
术后3月	15.74 ± 1.45^?	15.22 ± 1.18^?	2.17	0.030^#
术后6月	16.79 ± 0.93^?	16.49 ± 0.89^?	1.49	0.138
末次随访（≥ 12月）	17.26 ± 0.84^?	17.02 ± 0.95^?	1.31	0.191
ODI评分/%
治疗前	57.15 ± 7.82	58.37 ± 7.97	0.78	0.437
术后1 w	39.17 ± 8.89^?	43.61 ± 8.43^?	2.50	0.013^#
术后1月	27.94 ± 7.81^?	34.55 ± 8.05^?	4.21	< 0.001^#
术后3月	17.40 ± 4.10^?	21.98 ± 7.17^?	3.36	0.001^#
术后6月	12.23 ± 3.37^?	12.58 ± 3.18^?	0.72	0.473
末次随访（≥12月）	7.68 ± 2.03^?	7.96 ± 2.07^?	0.98	0.328
Macnab临床疗效评估/例			0.43	0.807
优	24	20
良	21	20
中	8	9
差	0	0
优良率/%	84.91	81.63

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Clinical observation of Endo⁃LOVE combined with NR⁃PRF in the treatment of LDD：Focusing on the improvement of postoperative residual symptoms

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