干细胞和巨噬细胞来源的外泌体对结肠炎的调控作用及其机制

doi:10.3969/j.issn.1006-5725.2025.03.022

Abstract

Abstract:

Colitis is a common inflammatory bowel disease whose pathogenesis is related to immune regulation and intestinal microbial homeostasis. Exosomes are membrane vesicles secreted by cells that contain proteins， lipids， and other substances. Stem cells and macrophages can participate in the regulation of related diseases by secreting exosomes. It has been found that exosomes of stem cell and macrophage origin are closely involved in the regulation of colitis， and exosomes derived from stem cells， especially mesenchymal stem cells， play an important role in anti-colitis. This article reviews the role and possible mechanisms of mesenchymal stem cell-based and macrophage-derived exosomes in the regulation of colitis， aiming to provide ideas for in-depth study of colitis and new strategies for its treatment.

Key words: exosome, colitis, mesenchymal stem cell, macrophage

CLC Number:

R574

Yijia LIU,Bin LIU,Kui HU,Yanfang CHEN,De. CAI. Regulatory effects and mechanisms of exosomes derived from stem cells and macrophages on colitis[J]. The Journal of Practical Medicine, 2025, 41(3): 447-453.

Figures/Tables 1

References 79

1	MARION-LETELLIER R， SAVOYE G， GHOSH S. IBD： In Food We Trust［J］. J Crohns Colitis， 2023，17（1）：149.
2	ROGLER G， SINGH A， KAVANAUGH A， et al. Extraintestinal Manifestations of Inflammatory Bowel Disease： Current Concepts， Treatment， and Implications for Disease Management［J］. Gastroenterology， 2021，161（4）：1118-1132. doi:10.1053/j.gastro.2021.07.042 doi: 10.1053/j.gastro.2021.07.042
3	CARON B， HONAP S， PEYRIN-BIROULET L. Epidemiology of Inflammatory Bowel Disease across the Ages in the Era of Advanced Therapies［J］. J Crohns Colitis， 2024，18（）：ii3-ii15. doi:10.1093/ecco-jcc/jjae082 doi: 10.1093/ecco-jcc/jjae082
4	RUDRAPRASAD D， RAWAT A， JOSEPH J. Exosomes， extracellular vesicles and the eye［J］. Exp Eye Res， 2022，214：108892. doi:10.1016/j.exer.2021.108892 doi: 10.1016/j.exer.2021.108892
5	LEE K M， SEO E C， LEE J H， et al. The Multifunctional Protein Syntenin-1： Regulator of Exosome Biogenesis， Cellular Function， and Tumor Progression［J］. Int J Mol Sci， 2023，24（11）：9418. doi:10.3390/ijms24119418 doi: 10.3390/ijms24119418
6	YE L， LI Y， ZHANG S， et al. Exosomes-regulated lipid metabolism in tumorigenesis and cancer progression［J］. Cytokine Growth F R， 2023，73：27-39. doi:10.1016/j.cytogfr.2023.05.002 doi: 10.1016/j.cytogfr.2023.05.002
7	YANG D， ZHANG W， ZHANG H， et al. Progress， opportunity， and perspective on exosome isolation-efforts for efficient exosome-based theranostics［J］. Theranostics， 2020，10（8）：3684-3707. doi:10.7150/thno.41580 doi: 10.7150/thno.41580
8	BEHERA J， KUMAR A， VOOR M J， et al. Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice［J］. Theranostics， 2021，11（16）：7715-7734. doi:10.7150/thno.58410 doi: 10.7150/thno.58410
9	KIMIZ-GEBOLOGLU I， ONCEL S S. Exosomes： Large-scale production， isolation， drug loading efficiency， and biodistribution and uptake［J］. J Control Release， 2022，347：533-543. doi:10.1016/j.jconrel.2022.05.027 doi: 10.1016/j.jconrel.2022.05.027
10	MONDAL J， PILLARISETTI S， JUNNUTHULA V， et al. Hybrid exosomes， exosome-like nanovesicles and engineered exosomes for therapeutic applications［J］. J Control Release， 2023，353：1127-1149. doi:10.1016/j.jconrel.2022.12.027 doi: 10.1016/j.jconrel.2022.12.027
11	KRYLOVA S V， FENG D. The Machinery of Exosomes： Biogenesis， Release， and Uptake［J］. Int J Mol Sci， 2023，24（2）：1337. doi:10.3390/ijms24021337 doi: 10.3390/ijms24021337
12	CHAN B D， WONG W Y， LEE M M， et al. Exosomes in Inflammation and Inflammatory Disease［J］. Proteomics， 2019，19（8）：e1800149. doi:10.1002/pmic.201800149 doi: 10.1002/pmic.201800149
13	YANG Y， PENG Y， LI Y， et al. Role of stem cell derivatives in inflammatory diseases［J］. Front Immunol， 2023，14：1153901. doi:10.3389/fimmu.2023.1153901 doi: 10.3389/fimmu.2023.1153901
14	GHAFOURI-FARD S， NIAZI V， HUSSEN B M， et al. The Emerging Role of Exosomes in the Treatment of Human Disorders With a Special Focus on Mesenchymal Stem Cells-Derived Exosomes［J］. Front Cell Dev Biol， 2021，9：653296. doi:10.3389/fcell.2021.653296 doi: 10.3389/fcell.2021.653296
15	GUPTA S， SARANGI P P. Inflammation driven metabolic regulation and adaptation in macrophages［J］. Clin Immunol， 2023，246：109216. doi:10.1016/j.clim.2022.109216 doi: 10.1016/j.clim.2022.109216
16	HARRELL C R， JOVICIC N， DJONOV V， et al. Therapeutic Use of Mesenchymal Stem Cell-Derived Exosomes： From Basic Science to Clinics［J］. Pharmaceutics， 2020，12（5）：474. doi:10.3390/pharmaceutics12050474 doi: 10.3390/pharmaceutics12050474
17	DING J Y， CHEN M J， WU L F， et al. Mesenchymal stem cell-derived extracellular vesicles in skin wound healing： roles， opportunities and challenges［J］. Mil Med Res， 2023，10（1）：36. doi:10.1186/s40779-023-00472-w doi: 10.1186/s40779-023-00472-w
18	HIGASHIYAMA M， HOKARI R. New and Emerging Treatments for Inflammatory Bowel Disease［J］. Digestion， 2023，104（1）：74-81. doi:10.1159/000527422 doi: 10.1159/000527422
19	WANG C， XU M， FAN Q， et al. Therapeutic potential of exosome-based personalized delivery platform in chronic inflammatory diseases［J］. Asian J Pharm Sci， 2023，18（1）：100772. doi:10.1016/j.ajps.2022.100772 doi: 10.1016/j.ajps.2022.100772
20	WANG X， ZHOU G， ZHOU W， et al. Exosomes as a New Delivery Vehicle in Inflammatory Bowel Disease［J］. Pharmaceutics， 2021，13（10）：1644. doi:10.3390/pharmaceutics13101644 doi: 10.3390/pharmaceutics13101644
21	NOONIN C， THONGBOONKERD V. Exosome-inflammasome crosstalk and their roles in inflammatory responses［J］. Theranostics， 2021，11（9）：4436-4451. doi:10.7150/thno.54004 doi: 10.7150/thno.54004
22	WEI S， WU X， CHEN M， et al. Exosomal-miR-129-2-3p derived from Fusobacterium nucleatum-infected intestinal epithelial cells promotes experimental colitis through regulating TIMELESS-mediated cellular senescence pathway［J］. Gut Microbes， 2023，15（1）：2240035. doi:10.1080/19490976.2023.2240035 doi: 10.1080/19490976.2023.2240035
23	LI DF， YANG MF， XU J， et al. Extracellular Vesicles： The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease［J］. Int J Nanomedicine， 2022，17：3893-3911. doi:10.2147/ijn.s370784 doi: 10.2147/ijn.s370784
24	FABIÁN O， KAMARADOVÁ K. Morphology of inflammatory bowel diseases （IBD）［J］. Cesk Patol， 2022，58（1）：27-37.
25	SAEZ A， HERRERO-FERNANDEZ B， GOMEZ-BRIS R， et al. Pathophysiology of Inflammatory Bowel Disease： Innate Immune System［J］. Int J Mol Sci， 2023，24（2）：1526. doi:10.3390/ijms24021526 doi: 10.3390/ijms24021526
26	DANNE C， SKERNISKYTE J， MARTEYN B， et al. Neutrophils： from IBD to the gut microbiota［J］. Nat Rev Gastro Hepat， 2024，21（3）：184-197. doi:10.1038/s41575-023-00871-3 doi: 10.1038/s41575-023-00871-3
27	EINAV L， HIRSCH A， RON Y， et al. Risk Factors for Malnutrition among IBD Patients［J］. Nutrients， 2021，13（11）：4098. doi:10.3390/nu13114098 doi: 10.3390/nu13114098
28	VAN EATON J， HATCH Q M. Surgical Emergencies in Inflammatory Bowel Disease［J］. Surg Clin North Am， 2024，104（3）：685-699. doi:10.1016/j.suc.2023.11.012 doi: 10.1016/j.suc.2023.11.012
29	SHAH S C， ITZKOWITZ S H. Colorectal Cancer in Inflammatory Bowel Disease： Mechanisms and Management［J］.Gastroenterology，2022，162（3）：715-730.e3. doi:10.1053/j.gastro.2021.10.035 doi: 10.1053/j.gastro.2021.10.035
30	YASMIN F， NAJEEB H， SHAIKH S， et al. Novel drug delivery systems for inflammatory bowel disease［J］. World J Gastroenterol， 2022，28（18）：1922-1933. doi:10.3748/wjg.v28.i18.1922 doi: 10.3748/wjg.v28.i18.1922
31	MUZAMMIL M A， FARIHA F， PATEL T， et al. Advancements in Inflammatory Bowel Disease： A Narrative Review of Diagnostics， Management， Epidemiology， Prevalence， Patient Outcomes， Quality of Life， and Clinical Presentation［J］. Cureus， 2023，15（6）：e41120.
32	TRIANTAFILLIDIS J K， ZOGRAFOS C G， KONSTADOULAKIS M M， et al. Combination treatment of inflammatory bowel disease： Present status and future perspectives［J］. World J Gastroentero， 2024，30（15）：2068-2080. doi:10.3748/wjg.v30.i15.2068 doi: 10.3748/wjg.v30.i15.2068
33	SEMENOVA E， GRUDNIAK M P， MACHAJ E K， et al. Mesenchymal Stromal Cells from Different Parts of Umbilical Cord： Approach to Comparison & Characteristics［J］. Stem Cell Rev Rep， 2021，17（5）：1780-1795. doi:10.1007/s12015-021-10157-3 doi: 10.1007/s12015-021-10157-3
34	MEBARKI M， ABADIE C， LARGHERO J， et al. Human umbilical cord-derived mesenchymal stem/stromal cells： A promising candidate for the development of advanced therapy medicinal products［J］. Stem Cell Res Ther， 2021，12（1）：152. doi:10.1186/s13287-021-02222-y doi: 10.1186/s13287-021-02222-y
35	HEIDARI N， ABBASI-KENARSARI H， NAMAKI S， et al. Regulation of the Th17/Treg balance by human umbilical cord mesenchymal stem cell-derived exosomes protects against acute experimental colitis［J］. Exp Cell Res， 2022，419（1）：113296. doi:10.1016/j.yexcr.2022.113296 doi: 10.1016/j.yexcr.2022.113296
36	CAI X， ZHANG Z Y， YUAN J T， et al. hucMSC-derived exosomes attenuate colitis by regulating macrophage pyroptosis via the miR-378a-5p/NLRP3 axis［J］. Stem Cell Res Ther， 2021，12（1）：416. doi:10.1186/s13287-021-02492-6 doi: 10.1186/s13287-021-02492-6
37	WANG J， PEI B， YAN J， et al. hucMSC-Derived Exosomes Alleviate the Deterioration of Colitis via the miR-146a/SUMO1 Axis［J］. Mol Pharm， 2022，19（2）：484-493. doi:10.1021/acs.molpharmaceut.1c00450 doi: 10.1021/acs.molpharmaceut.1c00450
38	XU Y， TANG X， FANG A， et al. HucMSC-Ex carrying miR-203a-3p.2 ameliorates colitis through the suppression of caspase11/4-induced macrophage pyroptosis［J］. Int Immunopharmacol， 2022，110：108925. doi:10.1016/j.intimp.2022.108925 doi: 10.1016/j.intimp.2022.108925
39	SHEN Q， HUANG Z， YAO J， et al. Extracellular vesicles-mediated interaction within intestinal microenvironment in inflammatory bowel disease［J］. J Adv Res， 2021，37：221-233. doi:10.1016/j.jare.2021.07.002 doi: 10.1016/j.jare.2021.07.002
40	YANG S， LIANG X， SONG J， et al. A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6［J］. Stem Cell Res Ther， 2021，12（1）：315. doi:10.1186/s13287-021-02404-8 doi: 10.1186/s13287-021-02404-8
41	LIANG X， LI C， SONG J， et al. HucMSC-Exo Promote Mucosal Healing in Experimental Colitis by Accelerating Intestinal Stem Cells and Epithelium Regeneration via Wnt Signaling Pathway［J］. Int J Nanomed， 2023，18：2799-2818. doi:10.2147/ijn.s402179 doi: 10.2147/ijn.s402179
42	WEI Z， HANG S， WIREDU OCANSEY D K， et al. Human umbilical cord mesenchymal stem cells derived exosome shuttling mir-129-5p attenuates inflammatory bowel disease by inhibiting ferroptosis［J］. J Nanobiotechnol， 2023，21（1）：188. doi:10.1186/s12951-023-01951-x doi: 10.1186/s12951-023-01951-x
43	BUNNELL B A. Adipose Tissue-Derived Mesenchymal Stem Cells［J］. Cells， 2021，10（12）：3433. doi:10.3390/cells10123433 doi: 10.3390/cells10123433
44	LEE J H， LÖTVALL J， CHO B S. The Anti-Inflammatory Effects of Adipose Tissue Mesenchymal Stem Cell Exosomes in a Mouse Model of Inflammatory Bowel Disease［J］. Int J Mol Sci， 2023，24（23）：16877. doi:10.3390/ijms242316877 doi: 10.3390/ijms242316877
45	HEIDARI N， ABBASI-KENARSARI H， NAMAKI S， et al. Adipose-derived mesenchymal stem cell-secreted exosome alleviates dextran sulfate sodium-induced acute colitis by Treg cell induction and inflammatory cytokine reduction［J］. J Cell Physiol， 2021，236（8）：5906-5920. doi:10.1002/jcp.30275 doi: 10.1002/jcp.30275
46	SHAPOURI-MOGHADDAM A， MOHAMMADIAN S， VAZINI H， et al. Macrophage plasticity， polarization， and function in health and disease［J］. J Cell Physiol， 2018，233（9）：6425-6440. doi:10.1002/jcp.26429 doi: 10.1002/jcp.26429
47	KADOMOTO S， IZUMI K， MIZOKAMI A. Macrophage Polarity and Disease Control［J］. Int J Mol Sci， 2021，23（1）：144. doi:10.3390/ijms23010144 doi: 10.3390/ijms23010144
48	QIAN W， HUANG L， XU Y， et al. Hypoxic ASCs-derived Exosomes Attenuate Colitis by Regulating Macrophage Polarization via miR-216a-5p/HMGB1 Axis ［J］. Inflamm Bowel Dis， 2023，29（9）：1515. doi:10.1093/ibd/izad101 doi: 10.1093/ibd/izad101
49	HEO JS， KIM S. Human adipose mesenchymal stem cells modulate inflammation and angiogenesis through exosomes［J］. Sci Rep， 2022，12（1）：2776. doi:10.1038/s41598-022-06824-1 doi: 10.1038/s41598-022-06824-1
50	CHU D T， PHUONG T N T， TIEN N L B， et al. An Update on the Progress of Isolation， Culture， Storage， and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells［J］. Int J Mol Sci， 2020，21（3）：708. doi:10.3390/ijms21030708 doi: 10.3390/ijms21030708
51	ZHU F， WEI C， WU H， et al. Hypoxic mesenchymal stem cell-derived exosomes alleviate ulcerative colitis injury by limiting intestinal epithelial cells reactive oxygen species accumulation and DNA damage through HIF-1α［J］. Int Immunopharmacol， 2022，113（Pt A）：109426. doi:10.1016/j.intimp.2022.109426 doi: 10.1016/j.intimp.2022.109426
52	YANG J， LIU XX， FAN H， et al. Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation， Oxidative Stress and Apoptosis［J］. PLoS One， 2015，10（10）：e0140551. doi:10.1371/journal.pone.0140551 doi: 10.1371/journal.pone.0140551
53	LIU H， LIANG Z， WANG F， et al. Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism［J］. JCI Insight， 2019，4（24）：e131273. doi:10.1172/jci.insight.131273 doi: 10.1172/jci.insight.131273
54	SUN D， CAO H， YANG L， et al. MiR-200b in heme oxygenase-1-modified bone marrow mesenchymal stem cell-derived exosomes alleviates inflammatory injury of intestinal epithelial cells by targeting high mobility group box 3［J］. Cell Death Dis， 2020，11（6）：480. doi:10.1038/s41419-020-2685-8 doi: 10.1038/s41419-020-2685-8
55	CHU S， YU T， WANG W， et al. Exosomes derived from EphB2-overexpressing bone marrow mesenchymal stem cells regulate immune balance and repair barrier function［J］. Biotechnol Lett， 2023，45（5-6）：601-617. doi:10.1007/s10529-023-03358-y doi: 10.1007/s10529-023-03358-y
56	TIAN J， ZHU Q， ZHANG Y， et al. Olfactory Ecto-Mesenchymal Stem Cell-Derived Exosomes Ameliorate Experimental Colitis via Modulating Th1/Th17 and Treg Cell Responses［J］. Front Immunol， 2020，11：598322. doi:10.3389/fimmu.2020.598322 doi: 10.3389/fimmu.2020.598322
57	CHANG Y， ZHANG Y， JIANG Y， et al. From Hair to Colon： Hair Follicle-Derived MSCs Alleviate Pyroptosis in DSS-Induced Ulcerative Colitis by Releasing Exosomes in a Paracrine Manner［J］. Oxid Med Cell Longev， 2022，2022：9097530. doi:10.1155/2022/9097530 doi: 10.1155/2022/9097530
58	DENG C， ZHANG H， LI Y， et al. Exosomes derived from mesenchymal stem cells containing berberine for ulcerative colitis therapy［J］. J Colloid Interface Sci， 2024，671：354-373. doi:10.1016/j.jcis.2024.05.162 doi: 10.1016/j.jcis.2024.05.162
59	YANG R， LIAO Y， WANG L， et al. Exosomes Derived From M2b Macrophages Attenuate DSS-Induced Colitis［J］. Front Immunol， 2019，10：2346. doi:10.3389/fimmu.2019.02346 doi: 10.3389/fimmu.2019.02346
60	DENG F， YAN J， LU J， et al. M2 Macrophage-Derived Exosomal miR-590-3p Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via the LATS1/YAP/ β-Catenin Signalling Axis［J］. J Crohns Colitis， 2021，15（4）：665-677. doi:10.1093/ecco-jcc/jjaa214 doi: 10.1093/ecco-jcc/jjaa214
61	LU H， SUO Z， LIN J， et al. Monocyte-macrophages modulate intestinal homeostasis in inflammatory bowel disease［J］. Biomark Res， 2024，12（1）：76. doi:10.1186/s40364-024-00612-x doi: 10.1186/s40364-024-00612-x
62	YIP J L K， BALASURIYA G K， SPENCER S J， et al. The Role of Intestinal Macrophages in Gastrointestinal Homeostasis： Heterogeneity and Implications in Disease［J］. Cell Mol Gastroenter， 2021，12（5）：1701-1718. doi:10.1016/j.jcmgh.2021.08.021 doi: 10.1016/j.jcmgh.2021.08.021
63	DU R， CHEN S， HAN C， et al. M1 intestinal macrophages-derived exosomes promote colitis progression and mucosal barrier injury［J］. Aging （Albany NY）， 2024，16（6）：5703-5710. doi:10.18632/aging.205672 doi: 10.18632/aging.205672
64	LU J， LIU D， TAN Y， et al. M1 Macrophage exosomes MiR-21a-5p aggravates inflammatory bowel disease through decreasing E-cadherin and subsequent ILC2 activation［J］. J Cell Mol Med， 2021，25（6）：3041-3050. doi:10.1111/jcmm.16348 doi: 10.1111/jcmm.16348
65	CHANG X， SONG Y H， XIA T， et al. Macrophage-derived exosomes promote intestinal mucosal barrier dysfunction in inflammatory bowel disease by regulating TMIGD1 via mircroRNA-223［J］. Int Immunopharmacol， 2023，121：110447. doi:10.1016/j.intimp.2023.110447 doi: 10.1016/j.intimp.2023.110447
66	ABDOLMOHAMMADI K， MAHMOUDI T， ALIMOHAMMADI M， et al. Mesenchymal stem cell-based therapy as a new therapeutic approach for acute inflammation［J］. Life Sci， 2023，312：121206. doi:10.1016/j.lfs.2022.121206 doi: 10.1016/j.lfs.2022.121206
67	HEGARTY L M， JONES G R， BAIN C C. Macrophages in intestinal homeostasis and inflammatory bowel disease［J］. Nat Rev Gastro Hepat， 2023，20（8）：538-553. doi:10.1038/s41575-023-00769-0 doi: 10.1038/s41575-023-00769-0
68	LI D F， TANG Q， YANG M F， et al. Plant-derived exosomal nanoparticles： potential therapeutic for inflammatory bowel disease［J］. Nanoscale Adv， 2023，5（14）：3575-3588. doi:10.1039/d3na00093a doi: 10.1039/d3na00093a
69	CAI Y， ZHANG L， ZHANG Y， et al. Plant-Derived Exosomes as a Drug-Delivery Approach for the Treatment of Inflammatory Bowel Disease and Colitis-Associated Cancer［J］. Pharmaceutics， 2022，14（4）：822. doi:10.3390/pharmaceutics14040822 doi: 10.3390/pharmaceutics14040822
70	ZHU Z， LIAO L， GAO M， et al. Garlic-derived exosome-like nanovesicles alleviate dextran sulphate sodium-induced mouse colitis via the TLR4/MyD88/NF-κB pathway and gut microbiota modulation［J］. Food Funct， 2023，14（16）：7520-7534. doi:10.1039/d3fo01094e doi: 10.1039/d3fo01094e
71	KIM J， ZHANG S， ZHU Y， et al. Amelioration of colitis progression by ginseng-derived exosome-like nanoparticles through suppression of inflammatory cytokines［J］. J Ginseng Res， 2023，47（5）：627-637. doi:10.1016/j.jgr.2023.01.004 doi: 10.1016/j.jgr.2023.01.004
72	KANG M， KANG M， LEE J， et al. Allium tuberosum-derived nanovesicles with anti-inflammatory properties prevent DSS-induced colitis and modify the gut microbiome［J］. Food Funct， 2024，15（14）：7641-7657. doi:10.1039/d4fo01366b doi: 10.1039/d4fo01366b
73	ZHU M Z， XU H M， LIANG Y J， et al. Edible exosome-like nanoparticles from portulaca oleracea L mitigate DSS-induced colitis via facilitating double-positive CD4+CD8+T cells expansion［J］. J Nanobiotechnol， 2023，21（1）：309. doi:10.1186/s12951-023-02065-0 doi: 10.1186/s12951-023-02065-0
74	SRIWASTVA M K， DENG Z B， WANG B， et al. Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway［J］. EMBO Rep， 2022，23（3）：e53365. doi:10.15252/embr.202153365 doi: 10.15252/embr.202153365
75	NAZARI H， ALBORZI F， HEIRANI-TABASI A， et al. Evaluating the safety and efficacy of mesenchymal stem cell-derived exosomes for treatment of refractory perianal fistula in IBD patients： clinical trial phase I［J］. Gastroenterol Rep （Oxf）， 2022，10：goac075. doi:10.1093/gastro/goac075 doi: 10.1093/gastro/goac075
76	HADIZADEH A， AKBARI-ASBAGH R， HEIRANI-TABASI A， et al. Localized Administration of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Refractory Perianal Fistula in Crohn's Disease Patients： A Phase II Clinical Trial［J］. Dis Colon Rectum， 2024，67（12）：p 1564-1575. doi:10.1097/dcr.0000000000003502 doi: 10.1097/dcr.0000000000003502
77	CLUA-FERRÉ L， SUAU R， VAÑÓ-SEGARRA I， et al. Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles： A focus on inflammatory bowel disease［J］. Clin Transl Med， 2024，14（11）：e70075. doi:10.1002/ctm2.70075 doi: 10.1002/ctm2.70075
78	GAN J， SUN L， CHEN G， et al. Mesenchymal Stem Cell Exosomes Encapsulated Oral Microcapsules for Acute Colitis Treatment［J］. Adv Healthc Mater， 2022，11（17）：e2201105. doi:10.1002/adhm.202201105 doi: 10.1002/adhm.202201105
79	DENG C， HU Y， CONCEIÇÃO M， et al. Oral delivery of layer-by-layer coated exosomes for colitis therapy［J］. J Control Release， 2023，354：635-650. doi:10.1016/j.jconrel.2023.01.017 doi: 10.1016/j.jconrel.2023.01.017

[1]	Junjie ZHAI,Shaoying WEN,Xinru LI,Rui SUN,Ning QI,Qifan ZHANG,Li YANG,Hui HUANG,Lingju MA,Yinju HAO,Yideng JIANG,Guizhong LI,Shengchao. MA. Role of Toll⁃like receptor 4 in regulation of homocysteine⁃induced ferroptosis in macrophages [J]. The Journal of Practical Medicine, 2025, 41(3): 313-321.
[2]	Huiling CAO,Jie ZHANG,Xiaofei ZHU,Shining QIAN,Yunfeng. CHEN. Study on the mechanism of tetramethylpyrazine pretreatment umbilical cord mesenchymal stem cell transplantation in the treatment of ischemic stroke [J]. The Journal of Practical Medicine, 2025, 41(2): 178-185.
[3]	Xingyu WAN,Nan LI,Shuiqing LIU,Xi. ZHANG. Research advances of mesenchymal stem cells in the bone marrow microenvironment of acute myeloid leukemia [J]. The Journal of Practical Medicine, 2025, 41(2): 294-299.
[4]	Chunyan LI,Ting XIAO,Bangcui WU,Yong CHEN,Mei TIAN. PKCβ inhibitor modulates macrophage phenotype and affects kidney ischemia-reperfusion injury during transplantation [J]. The Journal of Practical Medicine, 2025, 41(1): 23-29.
[5]	Rongmao HE,Zeyang FANG,Yunyun ZHANG,Youliang WU,Shixiu LIANG,Siqi WANG. Protective effect of basic alkaline ceramidase 1 in ulcerative colitis [J]. The Journal of Practical Medicine, 2025, 41(1): 7-14.
[6]	Jing LIU,Chuntao LENG,Yan. WANG. Study on the angiogenic ability of exosomes derived from dental pulp stem cells modified by circRNA SIPA1L1 [J]. The Journal of Practical Medicine, 2024, 40(9): 1211-1217.
[7]	Xiaona MENG,Xu SUN,Huaimin LIU. Advances in the study of immune checkpoint inhibitors⁃related colitis [J]. The Journal of Practical Medicine, 2024, 40(9): 1314-1319.
[8]	Fu CHEN,Bin LIU,Shuaijun HE,Yong ZHAO,Weizhou. WANG. The relationship between semen quality and trace element levels in seminal plasma and miR⁃184 levels in seminal vesicles of male infertility patients [J]. The Journal of Practical Medicine, 2024, 40(7): 930-935.
[9]	Li XIAO,Shumin LUO,Fang XU,Pengpeng LU,Enhong XING,Weihua. LI. Effect of culture time on immune⁃related membrane proteins of mouse dendritic cells and their exosomes [J]. The Journal of Practical Medicine, 2024, 40(7): 941-947.
[10]	Yuxin CHENG,Liang LIU,Shiyu DONG,Shengchao LI,Meng ZHANG. Research advances in exosomal proteins， mRNA and non⁃coding RNA regulation of Hepatocellular Carcinoma [J]. The Journal of Practical Medicine, 2024, 40(6): 748-755.
[11]	Yong LIU,XiaoLei CHENG,Xiangli CUI,Hao TANG,Huanzhen CHEN. ROBO3 deficiency promotes chemotherapy⁃induced transition of macrophage to foam cell [J]. The Journal of Practical Medicine, 2024, 40(6): 787-795.
[12]	Yin HUA,Xiaoyan WANG,Zhen WANG,Yongning XIN,Shousheng. LIU. The relationship between ulcerative colitis and the risk of hypothyroidism： A two⁃mendelian randomization study [J]. The Journal of Practical Medicine, 2024, 40(6): 827-832.
[13]	Shu CHEN,Jinglei ZHANG,Kang RONG,Nan ZHANG,Weiyi SUN. Research progress of exosomes in distant metastasis and drug resistance of gastric cancer [J]. The Journal of Practical Medicine, 2024, 40(6): 870-876.
[14]	Yujun YI,Xiaoming ZHAI,Huiling LIU,Jin. TAO. The role of PTTG1 in colonic inflammation by regulating intestinal epithelial cells pyroptosis [J]. The Journal of Practical Medicine, 2024, 40(5): 632-638.
[15]	Aiqin LI,Zhen ZHANG,Ya′nan XU,Jinyuan ZHU,Xu. ZHANG. Research progress on the interaction between macro⁃phages and fibroblasts in ARDS pulmonary fibrosis [J]. The Journal of Practical Medicine, 2024, 40(4): 571-574.

Regulatory effects and mechanisms of exosomes derived from stem cells and macrophages on colitis

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

Figures/Tables 1

References 79

Related Articles 15

Recommended Articles

Metrics

Comments