食管鳞状上皮内瘤变的研究进展

doi:10.3969/j.issn.1006-5725.2024.03.027

Abstract

Abstract:

China is a country with a high incidence of esophageal cancer. The pathological type is mainly squamous cell carcinoma. Squamous intraepithelial neoplasia is the most recognized precancerous lesion of esophageal squamous cell carcinoma， and its monitoring and intervention is an effective method to reduce the incidence of esophageal squamous cell carcinoma and improve the quality of life of patients. Understanding the etiology， clinical features， diagnosis and treatment of esophageal squamous cell carcinoma plays a crucial role in the prevention and early diagnosis and treatment of esophageal squamous cell carcinoma. At present， the clinical research related to esophageal squamous intraepithelial neoplasia is still insufficient， and there are some differences in clinical treatment. This review summarizes the risk factors， clinical features， diagnosis， prognosis and treatment of esophageal squamous intraepithelial neoplasia， hoping to provide ideas for the clinical management of esophageal squamous intraepithelial neoplasia.

Key words: esophagus, esophagus cancer, squamous intraepithelial neoplasia, Research progress

CLC Number:

R571

Shan GAO,Kun JI,Li ZHAO,Yujia XING,Yandong XIE,Xiqiang CAI. Research progress on esophageal squamous intraepithelial neoplasia[J]. The Journal of Practical Medicine, 2024, 40(3): 432-438.

References 50

1	陈茹，郑荣寿，张思维，等. 2015年中国食管癌发病和死亡情况分析［J］. 中华预防医学杂志， 2019（11）： 1094-1095.
2	ABNET C C， ARNOLD M， WEI W Q. Epidemiology of Esophageal Squamous Cell Carcinoma［J］. Gastroenterology， 2018，154（2）： 360-373. doi:10.1053/j.gastro.2017.08.023 doi: 10.1053/j.gastro.2017.08.023
3	ZENG H， CHEN W， ZHENG R， et al. Changing cancer survival in China during 2003-15： a pooled analysis of 17 population-based cancer registries［J］. Lancet Glob Health， 2018，6（5）： e555-e567. doi:10.1016/s2214-109x(18)30127-x doi: 10.1016/s2214-109x(18)30127-x
4	李鹏，王拥军，陈光勇，等. 中国早期食管鳞状细胞癌及癌前病变筛查与诊治共识（2015年，北京）［J］. 中华消化内镜杂志， 2016，33（1）： 3-18.
5	PAN D， SU M， ZHANG T， et al. A Distinct Epidemiologic Pattern of Precancerous Lesions of Esophageal Squamous Cell Carcinoma in a High-risk Area of Huai'an， Jiangsu Province， China［J］. Cancer Prev Res （Phila）， 2019，12（7）： 449-462. doi:10.1158/1940-6207.capr-18-0462 doi: 10.1158/1940-6207.capr-18-0462
6	SUN Y， ZHANG T， WU W， et al. Risk Factors Associated with Precancerous Lesions of Esophageal Squamous Cell Carcinoma： a Screening Study in a High Risk Chinese Population［J］. J Cancer， 2019，10（14）： 3284-3290. doi:10.7150/jca.29979 doi: 10.7150/jca.29979
7	NIU C， LIU Y， WANG J， et al. Risk factors for esophageal squamous cell carcinoma and its histological precursor lesions in China： a multicenter cross-sectional study［J］. BMC Cancer， 2021，21（1）： 1034. doi:10.1186/s12885-021-08764-x doi: 10.1186/s12885-021-08764-x
8	LU P， GU J， ZHANG N， et al. Risk factors for precancerous lesions of esophageal squamous cell carcinoma in high-risk areas of rural China： A population-based screening study［J］. Medicine （Baltimore）， 2020，99（31）： e21426. doi:10.1097/md.0000000000021426 doi: 10.1097/md.0000000000021426
9	MORITA M， KUMASHIRO R， KUBO N， et al. Alcohol drinking， cigarette smoking， and the development of squamous cell carcinoma of the esophagus： epidemiology， clinical findings， and prevention［J］. Int J Clin Oncol， 2010，15（2）：126-134. doi:10.1007/s10147-010-0056-7 doi: 10.1007/s10147-010-0056-7
10	YANG C X， WANG H Y， WANG Z M， et al. Risk factors for esophageal cancer： a case-control study in South-western China［J］. Asian Pac J Cancer Prev， 2005，6（1）：48-53.
11	EL-ZIMAITY H， DI PILATO V， NOVELLA RINGRESSI M， et al. Risk factors for esophageal cancer： emphasis on infectious agents［J］. Ann N Y Acad Sci， 2018，1434（1）：319-332. doi:10.1111/nyas.13858 doi: 10.1111/nyas.13858
12	ROSSI G， GAMBI R， UNCINI R， et al. Severe gastritis with double Helicobacter spp. infection associated with Barrett's esophagus in a cheetah［J］. Helicobacter， 2014，19（6）：462-464. doi:10.1111/hel.12151 doi: 10.1111/hel.12151
13	TAYLOR P R， ABNET C C， DAWSEY S M. Squamous dysplasia-the precursor lesion for esophageal squamous cell carcinoma［J］.Cancer Epidemiol Biomarkers Prev， 2013，22（4）： 540-552. doi:10.1158/1055-9965.epi-12-1347 doi: 10.1158/1055-9965.epi-12-1347
14	LIU X， ZHANG M， YING S， et al. Genetic Alterations in Esophageal Tissues From Squamous Dysplasia to Carcinoma［J］. Gastroenterology， 2017，153（1）：166-177. doi:10.1053/j.gastro.2017.03.033 doi: 10.1053/j.gastro.2017.03.033
15	ISHII T， MURAKAMI J， NOTOHARA K， et al. Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa［J］. Gut， 2007，56（1）：13-19. doi:10.1136/gut.2005.089813 doi: 10.1136/gut.2005.089813
16	SATO F， MELTZER S J. CpG island hypermethylation in progression of esophageal and gastric cancer ［J］. Cancer， 2006，106（3）：483-493. doi:10.1002/cncr.21657 doi: 10.1002/cncr.21657
17	WEI W Q， ABNET C C， LU N， et al. Risk factors for oesophageal squamous dysplasia in adult inhabitants of a high risk region of China［J］. Gut， 2005，54（6）：759-763. doi:10.1136/gut.2004.062331 doi: 10.1136/gut.2004.062331
18	SHIMIZU M， NAGATA K， YAMAGUCHI H，et al. Squamous intraepithelial neoplasia of the esophagus： past， present， and future［J］. J Gastroenterol， 2009，44（2）：103-112. doi:10.1007/s00535-008-2298-y doi: 10.1007/s00535-008-2298-y
19	MORI M， ADACHI Y， MATSUSHIMA T， et al.. Lugol staining pattern and histology of esophageal lesions［J］.Am J Gastroenterol， 1993，88（5）：701-705.
20	INOUE H， SASAJIMA K， KAGA M， et al. Endoscopic in vivo evaluation of tissue atypia in the esophagus using a newly designed integrated endocytoscope： a pilot trial［J］.Endoscopy， 2006，38（9）：891-895. doi:10.1055/s-2006-944667 doi: 10.1055/s-2006-944667
21	INOUE H， KAGA M， SATO Y， et al.Endoscopic diagnosis of tissue atypia （EA） in esophageal squamous epithelium—IPCL pattern classification and ECA classification （in Japanese with English abstract）［J］. Stomach Intest， 2007，42：161-171. doi:10.1002/9780470692394.ch5 doi: 10.1002/9780470692394.ch5
22	CIOCIRLAN M， LAPALUS M G， HERVIEU V，et al. Endoscopic mucosal resection for squamous premalignant and early malignant lesions of the esophagus［J］. Endoscopy， 2007，39：24-29. doi:10.1055/s-2006-945182 doi: 10.1055/s-2006-945182
23	ARIMA M， TADA M， ARIMA H. Evaluation of microvascular patterns of superficial esophageal cancers by magnifying endoscopy［J］. Esophagus， 2005，2：191-197. doi:10.1007/s10388-005-0060-6 doi: 10.1007/s10388-005-0060-6
24	SHIMAMURA Y， GODA K， HIROOKA S， et al. Observation of bilobed nucleus sign by endocytoscopy in eosinophilic esophagitis［J］. Gastrointest Endosc， 2021，93（1）：259-260. doi:10.1016/j.gie.2020.06.063 doi: 10.1016/j.gie.2020.06.063
25	DAWSEY S M， LEWIN K J， WANG G Q， et al. Squamous esophageal histology and subsequent risk of squamous cell carcinoma of the esophagus. A prospective follow-up study from Linxian， China［J］. Cancer， 1994，74（6）： 1686-1692. doi:10.1002/1097-0142(19940915)74:6<1686::aid-cncr2820740608>3.0.co;2-v doi: 10.1002/1097-0142(19940915)74:6<1686::aid-cncr2820740608>3.0.co;2-v
26	WANG G Q， ABNET C C， SHEN Q， et al. Histological precursors of oesophageal squamous cell carcinoma： results from a 13 year prospective follow up study in a high risk population［J］. Gut， 2005，54（2）： 187-192. doi:10.1136/gut.2004.046631 doi: 10.1136/gut.2004.046631
27	WEI W Q， HAO C Q， GUAN C T， et al. Esophageal Histological Precursor Lesions and Subsequent 8.5-Year Cancer Risk in a Population-Based Prospective Study in China［J］. Am J Gastroenterol， 2020，115（7）： 1036-1044. doi:10.14309/ajg.0000000000000640 doi: 10.14309/ajg.0000000000000640
28	朱林林，董培雯，粟兴，等. 食管黏膜低级别上皮内瘤变内镜特点及病理转归分析［J］. 四川大学学报（医学版）， 2018，49（6）： 849-853.
29	高冬青，史思达，杨佳，等. 食管癌高发区山东省肥城市2006年至2016年食管癌前病变转归情况分析［J］. 中国肿瘤临床， 2020，47（22）： 1159-1163. doi:10.3969/j.issn.1000-8179.2020.22.015 doi: 10.3969/j.issn.1000-8179.2020.22.015
30	王松，方放，陆恒，等. 食管黏膜病变术前活检与内镜术后病理的异同分析［J］. 医学研究杂志， 2018，47（1）： 145-148. doi:10.11969/j.issn.1673-548X.2018.01.036 doi: 10.11969/j.issn.1673-548X.2018.01.036
31	林丽萍，刘剑雄，林楠，等. 食管癌前病变术前活检与内镜黏膜下剥离术后病理结果的一致性分析［J］. 现代临床医学， 2021，47（3）： 173-175.
32	徐文，童强，刘晓波，等. 食管上皮内瘤变内镜活检与术后标本病理结果差异分析［J］. 临床消化病杂志， 2018，30（1）： 1-5. doi:10.3870/lcxh.j.issn.1005-541X.2018.01.01 doi: 10.3870/lcxh.j.issn.1005-541X.2018.01.01
33	朱肖男，董培雯，向玲亚，等. 食管低级别上皮内瘤变的内镜切除组织病理升级的危险因素分析［J］. 四川大学学报（医学版）， 2018，49（6）： 854-858.
34	YANG L， JIN H， XIE X L， et al. Endoscopic resections for superficial esophageal squamous cell epithelial neoplasia： focus on histological discrepancies between biopsy and resected specimens［J］. BMC Gastroenterol， 2021，21（1）： 114. doi:10.1186/s12876-021-01694-9 doi: 10.1186/s12876-021-01694-9
35	中国食管鳞癌癌前状态及癌前病变诊治策略专家共识［J］. 中华消化内镜杂志， 2020，37（12）： 853-867. doi:10.3760/cma.j.cn321463-20200928-00807 doi: 10.3760/cma.j.cn321463-20200928-00807
36	van MUNSTER S N， POUW R E， SHARMA V K， et al. Radiofrequency vapor ablation for Barrett's esophagus： feasibility， safety and proof of concept in a stepwise study with in vitro， animal， and the first in-human application［J］. Endoscopy， 2021，53（11）： 1162-1168. doi:10.1055/a-1319-5550 doi: 10.1055/a-1319-5550
37	HE S， BERGMAN J， ZHANG Y， et al. Endoscopic radiofrequency ablation for early esophageal squamous cell neoplasia： report of safety and effectiveness from a large prospective trial［J］. Endoscopy， 2015，47（5）： 398-408. doi:10.1055/s-0034-1391285 doi: 10.1055/s-0034-1391285
38	YU X， van MUNSTER S N， ZHANG Y， et al. Durability of radiofrequency ablation for treatment of esophageal squamous cell neoplasia： 5-year follow-up of a treated cohort in China［J］. Gastrointest Endosc， 2019，89（4）： 736-748. doi:10.1016/j.gie.2018.10.030 doi: 10.1016/j.gie.2018.10.030
39	陈思杰，邹清云，黄中华，等. 内镜下氩离子凝固术治疗食管低级别上皮内瘤变的临床研究［J］. 中国消化内镜， 2009，3（4）： 1-4.
40	LAL P， THOTA P N. Cryotherapy in the management of premalignant and malignant conditions of the esophagus［J］. World J Gastroenterol， 2018，24（43）： 4862-4869. doi:10.3748/wjg.v24.i43.4862 doi: 10.3748/wjg.v24.i43.4862
41	KAWASHIMA K， ABE S， KOGA M， et al. Optimal selection of endoscopic resection in patients with esophageal squamous cell carcinoma： endoscopic mucosal resection versus endoscopic submucosal dissection according to lesion size［J］. Dis Esophagus， 2021，34（5）：doaao96. doi:10.1093/dote/doaa096 doi: 10.1093/dote/doaa096
42	HAN C， SUN Y. Efficacy and safety of endoscopic submucosal dissection versus endoscopic mucosal resection for superficial esophageal carcinoma： a systematic review and meta-analysis［J］. Dis Esophagus， 2021，34（4）：doaao81. doi:10.1093/dote/doaa081 doi: 10.1093/dote/doaa081
43	李峰，伍平，陈非，等. 内镜下黏膜下剥离术和多环套扎黏膜切除术治疗早期食管癌对比研究［J］. 中国医师杂志， 2016，18（7）： 1058-1060. doi:10.3760/cma.j.issn.1008-1372.2016.07.029 doi: 10.3760/cma.j.issn.1008-1372.2016.07.029
44	PENG W， TAN S， REN Y， et al. Efficacy and safety of endoscopic submucosal tunnel dissection for superficial esophageal neoplastic lesions： a systematic review and meta-analysis［J］. J Cardiothorac Surg， 2020，15（1）： 33. doi:10.1186/s13019-020-1074-9 doi: 10.1186/s13019-020-1074-9
45	ZHANG W， ZHAI Y， CHAI N， et al. Single- and double-tunnel endoscopic submucosal tunnel dissection for large superficial esophageal squamous cell neoplasms［J］. Endoscopy， 2018，50（5）： 505-510. doi:10.1055/s-0043-122384 doi: 10.1055/s-0043-122384
46	ZHU L L， WU J C， WANG Y P， et al. Endoscopic Submucosal Single- or Multi-tunnel Dissection for Near-Circumferential and Circumferential Superficial Esophageal Neoplastic Lesions［J］. Gastroenterol Res Pract， 2019，2019： 2943232. doi:10.1155/2019/2943232 doi: 10.1155/2019/2943232
47	LIU B R， LIU D， YANG W， et al. Mucosal loss as a critical factor in esophageal stricture formation after mucosal resection： a pilot experiment in a porcine model［J］. Surg Endosc， 2020，34（2）： 551-556. doi:10.1007/s00464-019-06793-z doi: 10.1007/s00464-019-06793-z
48	张月明，贺舜，吕宁，等. 内镜下射频消融术治疗范围广泛的0-Ⅱb型早期食管鳞状细胞癌及癌前病变的临床效果［J］. 中华消化内镜杂志， 2015，32（9）： 586-590.
49	阿里木江·阿不都热合曼，纪文静，阿古再·热合曼. 内镜下射频消融术治疗早期范围广的表浅平坦型食管鳞状上皮细胞癌及癌前病变的临床疗效评价［J］. 中国医师杂志， 2017，19（6）： 905-907.
50	张月明， JACQUES JGHM BERGMAN，薛丽燕，等. 内镜下射频消融术联合内镜黏膜切除术治疗大面积非表浅平坦型早期食管鳞状细胞癌和癌前病变疗效初探［J］. 中华胃肠外科杂志， 2015，18（9）： 875-880. doi:10.3760/cma.j.issn.1671-0274.2015.09.007 doi: 10.3760/cma.j.issn.1671-0274.2015.09.007

[1]	Ganggang LU,Shenglong LI,Yongqiang ZHAO,Yunpeng JIA,Yonglin LIANG,Yuanbo. ZHAO. Research progress on the correlation between oxidative stress and ferroptosis in diabetic impotence [J]. The Journal of Practical Medicine, 2024, 40(16): 2229-2235.
[2]	Xin DOU,Changhui HE,Xiao MEI,Haidi PAN,Yuanxin MA,Wei. WANG. Research progress on the intervention of traditional Chinese medicine in IBS⁃D based on the "SCFAs⁃intestinal barrier" pathway [J]. The Journal of Practical Medicine, 2024, 40(15): 2177-2182.
[3]	Shan′gao HUANG,Yueling WU,Ying. ZHANG. Aiming for the future： The latest advances in targeted therapy for ovarian cancer [J]. The Journal of Practical Medicine, 2024, 40(14): 1901-1907.
[4]	Haixia YUAN,Xinmin HAN,Tianyi CHEN,Yuchen. SONG. Progress on structural abnormalities in the cerebral cortex in children with attention deficit/hyperactivity disorder [J]. The Journal of Practical Medicine, 2024, 40(10): 1455-1459.
[5]	Yadan CHE,Lixia. LI. Reaserch progress on small molecule anti⁃angiogenic drugs for advanced breast cancer [J]. The Journal of Practical Medicine, 2023, 39(22): 2866-2871.
[6]	LIU Hui, HE Caixian, PENG Jiyong, ZHONG Xi, LIAO Kai, YUAN Yawei, ZHENG Ronghui.. Carotid arterial injuries caused by radiotherapy for nasopharyngeal carcinoma：A review [J]. The Journal of Practical Medicine, 2023, 39(10): 1201-1205.
[7]	LI Yanwei, WANG Bin, MIAO Yulu, LI Xiao⁃ jin, ZHANG Yadong, HAN Juan, ZHUANG Pengwei, ZHANG Yanjun.. Research progress of intestinal barrier dysfunction in sepsis [J]. The Journal of Practical Medicine, 2022, 38(7): 799-803.
[8]	ZHANG Ying, WU Yueling.. Immunotherapy incervical cancer：The advent of precision medicine [J]. The Journal of Practical Medicine, 2022, 38(15): 1856-1859.
[9]	ZHANG Feng, JIAO Yaxing, XU Guangjian.. Evaluation of protective rehabilitation intervention for pulmonary ventilation function in patients undergo⁃ ing laparoscopic hiatal hernia repair complicated with GRED [J]. The Journal of Practical Medicine, 2022, 38(10): 1246-1250.
[10]	WAN Jingfang, CHEN Kehong.. Progress on preventing peritoneal fibrosis in peritoneal dialysis [J]. The Journal of Practical Medicine, 2022, 38(10): 1286-1291.
[11]	LI Liu, YU Jianhua. . Research progress on risk factors and prevention and treatment of AIDS ⁃related cardiovascular diseases [J]. The Journal of Practical Medicine, 2021, 37(20): 2687-2691.

Research progress on esophageal squamous intraepithelial neoplasia

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 50

Related Articles 11

Recommended Articles

Metrics

Comments