高甘油三酯葡萄糖乘积指数与腹膜透析患者病死率增加相关的队列研究

doi:10.3969/j.issn.1006-5725.2024.03.016

Abstract

Abstract:

Objective The objective of this study is to investigate whether there is a correlation between a high TyG index （serum triglyceride glucose index） and higher mortality rates among patients undergoing peritoneal dialysis （PD）. Methods This study utilized a single-center retrospective cohort as the basis for its methods.. From January 1，2007 to December 31，2015，a total of 519 PD patients kept under observation until December 31，2018. There searchers employed the Kaplan-Meier method and Cox proportional hazards modelsto examine the correlation between TyG index levels and mortality. Results Over a period of 40.5 months， 104 （20.0%） individuals with Parkinson's disease passed away， with 55 （52.9%） of these deaths attributed to cardiovascular disease （CVD）. The serum median TyG index at baseline was 8.44 （6.48， 11.94）. Through Cox regression analysis subject to the adjustments of such parameters as gender， age， body mass index（BMI）， presence of cardiovascular disease， hypertension， diabetes mellitus， hemoglobin， serum albumin， serum Ferritin， total cholesterol， renal residual function（RRF）， An increased risk of all-cause mortality （HR = 2.22，95%CI： 1.43 ~ 3.44，P < 0.001） and CVD mortality （HR = 2.50，95%CI： 1.34 ~ 4.65，P = 0.004） was observed with a higher baseline TyG index （8.44）. A comparable impact was observed in the correlation between the average TyG index over time（TA-TyG index）and both all-cause mortality and CVD mortality. （HR = 1.90， 95％CI： 1.25 ~ 2.90， P = 0.003； HR = 2.05， 95％CI： 1.14 ~ 3.70， P = 0.017，respectively）. Conclusion PD patients with a higher serum TyG index have a greater risk of all-cause mortality and mortality related to cardiovascular disease.

Key words: triglyceride glucose index, peritoneal dialysis, mortality

CLC Number:

R692.5

Shan YANG,Hongying LI,Jingxuan ZHOU,Yaode CHEN,Yaqin LI,Ziqi GU,Hongxin NIU. Association of high triglyceride glucose index with increased mortality in peritoneal dialysis： A cohort study[J]. The Journal of Practical Medicine, 2024, 40(3): 371-377.

Figures/Tables 5

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References 26

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项目	低TyG组（n = 259）	高TyG组（n = 260）	P值
年龄（岁）	50.3 ± 13.6	51.1 ± 14.8	0.492
男性［例（%）］	158（61.0）	148（56.9）	0.658
BMI（kg/m2）	21.73 ± 2.15	21.60 ± 2.24	0.727
收缩压（mmHg）	137.98 ± 16.23	138.42 ± 17.17	0.656
舒张压（mmHg）	83.16 ± 11.45	82.93 ± 12.62	0.724
并发症［例（%）］
CVD	59（22.8）	103（39.6）	0.001
糖尿病	68（26.3）	78（30.0）	0.344
高血压	108（41.7）	139（53.5）	0.007
白细胞（×10⁹·L^-1）	7.11 ± 2.55	7.27 ± 2.49	0.477
Hb（g/dL）	9.70 ± 2.04	9.81 ± 2.14	0.462
Alb（g/dL）	3.17 ± 0.39	3.26 ± 0.40	0.013
TC（mg/dL）	164.47 ± 43.51	180.09 ± 44.97	< 0.001
TG（mg/dL）	128.88 ± 81.53	158.10 ± 84.77	< 0.001
FPG（mg/dL）	90.49 ± 16.83	96.84 ± 16.78	< 0.001
HDL-C （mg/dL）	46.85 ± 17.18	45.26 ± 15.45	0.520
LDL-C （mg/dL）	105.16 ± 35.48	108.50 ± 40.70	0.320
血清UA（mg/dL）	6.97 ± 1.66	7.42 ± 2.01	0.005
血浆铁蛋白（ng/mL）	323.40 ± 105.59	390.54 ± 118.27	0.042
血清白蛋白校正钙（mg/dL）	8.42 ± 0.80	8.50 ± 0.96	0.411
血清磷（mg/dL）	6.01 ± 1.52	6.10 ± 1.49	0.362
血清肌酐（mg/dL）	8.84 ± 4.15	9.60 ± 2.77	0.132
总Kt/V	2.18 ± 0.57	1.98 ± 0.42	0.231
每周总肌酐清除率［L/（周·1.73 m²）］	61.54 ± 20.15	58.14 ± 20.44	0.158
残余肾功能［mL/（min·1.73 m²）］	4.43 ± 4.51	4.29 ± 4.50	0.773

项目	TyG指数*		TA-TyG指数^#
项目	HR（95%CI）	P值	HR（95%CI）	P值
全因死亡率
未校正	2.11（1.40 ~ 3.20）	< 0.001	1.95（1.30 ~ 2.91）	0.001
模型1	2.08（1.37 ~ 3.15）	0.001	1.87（1.25 ~ 2.82）	0.003
模型2	1.85（1.21 ~ 2.83）	0.005	1.82（1.20 ~ 2.75）	0.004
模型3	2.22（1.43 ~ 3.44）^a	< 0.001	1.90（1.25 ~ 2.90）^b	0.003
CVD死亡率
未校正	2.39（1.33 ~ 4.28）	0.004	2.18 （1.24 ~ 3.84）	0.007
模型 1	2.33（1.30 ~ 4.20）	0.005	2.09（1.18 ~ 3.70）	0.012
模型2	1.97（1.08 ~ 3.62）	0.028	1.98（1.11 ~ 3.53）	0.021
模型3	2.50（1.34 ~ 4.65）^a	0.004	2.05（1.14 ~ 3.70）^b	0.017

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Association of high triglyceride glucose index with increased mortality in peritoneal dialysis： A cohort study

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