Abstract:

Objective To study the effect of transcatheter aortic valve implantation （TAVI） on severe aortic stenosis （AS） complicated with mitral regurgitation （MR） of different degrees. Methods Retrospectively， 66 patients with severe aortic stenosis and TAVI surgery in Henan Provincial Chest Hospital from April 2020 to June 2022 were included and divided into group A （no regurgitation + mild regurgitation） and group B （moderate + severe regurgitation） according to presence or absence of MR as well as its severity. The changes in cardiac structure and function before and after operation and the effects of TAVI were compared between the two groups. Results The aortic valve peak gradient and aortic valve peak velocity in the two groups after operation were significantly improved compared with those before surgery （P < 0.05）， but there was no statistical difference between the two groups （P > 0.05）. In the moderate and severe mitral regurgitation group， the left atrial diameter ［39.00（37.00，42.00）mm］， left ventricular end diastolic diameter ［47.00（41.00，58.00）mm］， mitral regurgitation ［2.90（2.40，4.70）cm²］ and NT-ProBNP ［2 567.80（1 196.87，3 344.90） pg/mL］ were significantly lower than those before operation ［41.00（38.00，48.00）mm］， ［55.00（44.00，60.00）mm］， ［7.60（5.10，11.00）cm²］， ［4 649.05（2 132.54， 9 333.30）pg/mL］ （P < 0.05）， and LVEF was higher than before surgery ［50.00（42.00，61.00） vs. 45.00 （35.00， 62.00）， P < 0.05］. Conclusion TAVI can be used for the treatment of patients with AS combined with MR of different degrees and it is beneficial for patients with moderate to severe mitral regurgitation as well.

Key words: transcatheter aortic valve implantation, aortic stenosis, mitral regurgitation