The Journal of Practical Medicine ›› 2023, Vol. 39 ›› Issue (16): 2142-2147.doi: 10.3969/j.issn.1006-5725.2023.16.022

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Bidirectional regulation of tumor associated neutrophils and their role in urothelial bladder cancer: a literature review

Kai DENG1,Meng YANG1,Ling ZHANG1,Jun′an QIAN1,Yunqiang SHI1,Chunhui. WANG1,2()   

  1. *.Department of Urology,Yan'an Hospital,Kunming Medical University,Kunming 650000,China
  • Received:2023-05-10 Online:2023-08-25 Published:2023-09-26
  • Contact: Chunhui. WANG E-mail:337911033@qq.com

Abstract:

Urothelial bladder cancer (UBC) is one of the most common malignant tumors in urology, and its occurrence and progression are closely related to the tumor microenvironment (TME). Tumor-associated neutrophils (TAN), as an important type of immune cells in TME, have been proven to have anti-tumor or pro-tumor regulatory effects on various tumors, which are related to their heterogeneity and plasticity. The study on TAN′s bidirectional regulation may provide new targets for tumor treatment. This article reviews the current status of TAN′s bidirectional regulation research by searching recent literature, and summarizes its research progress in UBC.

Key words: urothelial bladder cancer, tumor-associated neutrophil, tumor microenvironment

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