磷脂酶A2在肝细胞癌发生发展过程中的作用

doi:10.3969/j.issn.1006-5725.2023.15.001

Abstract

Abstract:

Hepatocellular carcinoma （HCC） is one of the most common malignant tumors， and its high morbidity， high mortality rate， and low survival rate are the basic features of the epidemiology of HCC in China. It has been found that phospholipase A2（PLA2） is involved in the complex processes of phospholipid digestion and metabolism， immune defense and signaling， and actively participates in the inflammatory response of liver tissue， hepatocyte survival， proliferation and apoptosis， and the process of hepatocellular carcinogenesis and development. This paper introduces the role of PLA2 in the development of HCC and points out that PLA2 can be used as a new idea and drug target for drug development and clinical control of HCC.

Key words: hepatocellular carcinoma, phospholipase A2, hepatitis B virus, inflammatory response, hepatocarcinogenesis

LI Feiyan , ZHANG Riyun, WANG Na, WANG Minggang, MAO Dewen. . The role of phospholipase A2 in the development of Hepatocellular carcinoma [J]. The Journal of Practical Medicine, 2023, 39(15): 1857-1861.

[1]	Kanglin CAI,Jinkai ZHANG,Liangdi RAN,Dajun HU,Zhitao FENG,Huilian. HUANG. Research progress on antidepressant pharmacological effects and mechanisms of Bupleuri Radix⁃Paeoniae Radix Alba herb⁃pair [J]. The Journal of Practical Medicine, 2024, 40(4): 447-452.
[2]	Ting WANG,Li. HE. Application of leukocyte⁃and platelet⁃rich fibrin in dental pulp repair of rat [J]. The Journal of Practical Medicine, 2024, 40(14): 1941-1946.
[3]	Haibin WANG,Hui LI,Xiaolei CHEN,Na LIU,Quanmei LI,Yu ZOU,Chunmei LI,Jingquan GAN,Changhui WU,Huaxian CHEN,Xiang LIU,Ming. GONG. Effect of fasting plasma glucose level on the prognosis of disease in patients with HBV⁃related acute⁃on⁃chronic liver failure [J]. The Journal of Practical Medicine, 2023, 39(18): 2373-2378.
[4]	LI Ningkang, MA Tao, MA Xu, ZHOU Xiaohong, YANG Lifeng, ZHANG Lei, WANG Yun. . The effects of quadratus lumborum block on inflammatory response and postoperative intestinal function recovery in patients undergoing laparoscopic colorectal cancer surgery [J]. The Journal of Practical Medicine, 2023, 39(14): 1769-1773.
[5]	ZHANG Cuicui, SUN Wenping, XIE Ling.. miR⁃27a attenuates oxidative stress and inflammatory damage in diabetic pregnant rats by targeting TLR4 [J]. The Journal of Practical Medicine, 2023, 39(12): 1487-1493.
[6]	GUO Qingduo, YANG Qiuying, MA Meina, YU Hong, WANG Xupeng, WU Chunling, LI Rui, HE Qing.. Effects of dexmedetomidine on neurological function and JAK2/STAT3 pathway in rats with intracerebral hemorrhage [J]. The Journal of Practical Medicine, 2022, 38(9): 1094-1101.
[7]	LIU Mei, QI Min, DING Lei, YING Juan, HAN Yongfeng.. Energy efficiency of plasma TREM⁃2 combined with MELD score in predicting the near⁃term prognosis ofpatients with HBV⁃acute⁃on⁃chronic liver failure [J]. The Journal of Practical Medicine, 2022, 38(4): 473-478.
[8]	HU Lin, YANG Yanjuan, LI Jieying, ZHOU Zhong, TIAN Zheng, JIAO Rong. . Salidroside improves coronary artery injury in Kawasaki disease by activating PI3K/Akt and inhibiting NF ⁃ κB signaling pathway [J]. The Journal of Practical Medicine, 2022, 38(21): 2657-2669.
[9]	ZHANG Xue, # , ZHANG Liang, TANG Shan⁃ hong.. The prognostic value of neutrophil lymphocyte ratio and its dynamic changes in the treatment of chronic hepatitis B associated acute liver failure with artificial liver [J]. The Journal of Practical Medicine, 2022, 38(18): 2341-2345.
[10]	JIN Zhanyong, XIA Pengfei, QU Jianping, LIANG Jin.. Effects of Huoyuan Recipe combined with quadruple therapy on serum PG，TSGF and MG7⁃Ag levels in patients with Hp⁃positive chronic atrophic gastritis of spleen⁃stomach⁃qi deficiency type [J]. The Journal of Practical Medicine, 2022, 38(18): 2357-2362.
[11]	YANG Tao, JIA Zhaojin, SONG Jidong, WANG Dong, ZHANG Chunmei.. Effects of different doses of Icariin on coagulation function，inflammatory factors and fibrinolytic indexes of venous thrombosis model rats [J]. The Journal of Practical Medicine, 2022, 38(17): 2145-2150.
[12]	QIN Hewei, NIU Yuqing, SONG Xuemei, WANG Mengnan, SUN Mengyan.. Molecular mechanism of Xueguan Ruanhua Pill in preventing atherosclerosis through inhibiting vascular inflammation [J]. The Journal of Practical Medicine, 2022, 38(15): 1901-1907.
[13]	DENG Xiaoying, FAN Yongxiang, MO Zhiming, ZHANG Zhixin, ZHANG Bin.. Correlation of plasma lipoprotein phospholipase A2 level with cognitive impairment in patients with white matter hyperintensity [J]. The Journal of Practical Medicine, 2021, 37(7): 884-888.
[14]	HAN Chengmei, REN Yunhua, DING Lei. The evaluation value of COSSH⁃ACLF score combined with serum IL⁃37 level in short⁃term prognosis of patients with chronic hepatitis B Virus（HBV）associated with acute liver failure [J]. The Journal of Practical Medicine, 2021, 37(4): 472-476.
[15]	JI Peng, SUN Gen, QU Xueping, KOU Qixing, GUO Xiangdong, JIANG Limin.. The clinical study of lipoprotein⁃associated phospholipase A2 in predicting obstructive sleep apnea hypop⁃ nea syndrome with ischemic cerebrovascular disease [J]. The Journal of Practical Medicine, 2021, 37(17): 2229-2232.

The role of phospholipase A2 in the development of Hepatocellular carcinoma

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments