肠道屏障在肠易激综合征发病机制中的研究进展

doi:10.3969/j.issn.1006-5725.2025.16.023

摘要/Abstract

摘要：

肠易激综合征（irritable bowel syndrome， IBS）是一种常见的功能性肠道疾病，其病因复杂，涉及多种因素的相互作用。近年来，越来越多的研究表明，肠道屏障功能障碍可能在IBS的发病机制中发挥重要作用。该文综述了肠道屏障受损对IBS的影响，探讨肠道机械屏障、免疫屏障、化学屏障、生物屏障与IBS的相关性以及临床治疗，并提出未来研究应关注肠道屏障修复靶向的机制研究，为IBS的发病机制及治疗提供了新的视角和方向。

关键词: 肠易激综合征, 肠道屏障, 机械屏障, 化学屏障, 生物屏障, 免疫屏障, 研究进展

Abstract:

Irritable bowel syndrome （IBS） is a prevalent functional gastrointestinal disorder characterized by a complex etiology involving multiple interacting factors. Accumulating evidence in recent years has indicated that intestinal barrier dysfunction may play a crucial role in the pathogenesis of IBS. This review systematically examines the impact of intestinal barrier dysfunction on IBS， analyzing its associations with the mechanical， immune， chemical， and microbial components of the gut barrier， as well as current clinical treatment approaches. Moreover， this paper highlights the potential of intestinal barrier repair mechanisms as therapeutic targets， which may provide novel insights and directions for understanding the underlying pathophysiological mechanisms and developing effective interventions for IBS.

Key words: irritable bowel syndrome, intestinal barrier, mechanical barrier, chemical barrier, microbial barrier, immune barrier, research advances

中图分类号:

R574.4

何悦,程珂新,李艳秋,侯雨君,周思远. 肠道屏障在肠易激综合征发病机制中的研究进展[J]. 实用医学杂志, 2025, 41(16): 2597-2603.

Yue HE,Kexin CHENG,Yanqiu LI,Yujun HOU,Siyuan. ZHOU. Research progress on intestinal barrier in irritable bowel syndrome pathogenesis[J]. The Journal of Practical Medicine, 2025, 41(16): 2597-2603.

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