关键词: 单核细胞, 高密度脂蛋白胆固醇, 高血压, 无症状脑梗死

Abstract: Objective To investigate the relationship between monocyte/HDL-C ratio （MHR） and hypertension complicated with asymptomatic cerebral infarction（ACI）. Methods A total of 349 patients with hypertension, recruited from the Department of Hypertension, First Affiliated Hospital of Guangxi Medical University from January 2015 to March 2018 were enrolled in this study. They were divided into ACI group （ACI, n = 138） and non-complicating ACI group （NACI, n = 211） according to the Results of CT or MRI. Their Results of routine blood test, blood lipid level, kidney function and carotid ultrasound were collected. Logistic regression analysis was used to analysis influencing factors of hypertension complicated with ACI. In addition, receiver operating characteristic （ROC） curve was performed to assess the ability of influencing factors to predict ACI in patients with hypertension. Results There were significant differences in age, male ratio, course of hypertension, carotid plaque ratio, smoking ratio, alcohol consumption ratio, white blood cells, neutrophils, monocytes, MHR, serum creatinine, total cholesterol and high density lipoprotein cholesterol between the two groups （P < 0.05）. Logistic regression analysis showed that age, carotid plaque formation, MHR and creatinine elevation were independent risk factors for hypertension complicated with ACI （P < 0.05）. The area under curve （AUC） of MHR, age, serum creatinine and carotid plaque were 0.76, 0.69, 0.65 and 0.655, respectively （P < 0.001）. The predictive value of MHR was the highest. When the cut-off value was 10.29, the sensitivity and specificity were 70.3% and 63.0%, respectively. Conclusion MHR is significantly correlated to hypertension complicated with ACI, which is an independent risk factor of hypertension complicated with ACI. MHR can be regarded as a valuable indicator for risk screening.

Key words: monocyte, HDL-C, hypertension, asymptomatic cerebral infarction