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Abstract:

Objective The aim of thisstudy was to explore the clinical effect of anisodamine combined with montelukast in the treatment of HSP. Methods A total of 120 patients with henoch schonlein purpura were randomly divided into observation group（60 cases）and control group（60 cases）. Both groups were treated with montelukast，while patients in observation group were treated with Anisodamine for 4 weeks. The effect，symptom improvement，stress response，inflammatory factors and recurrence rate were compared between the two groups. Meanwhile，the recurrence risk factors were analyzed. Results The total effective rate of the observation group （93.33%）was significantly higher than that of the control group（73.33%）. The disappearance time of purpura， abdominal pain，joint swelling and pain，the levels of IL⁃4，IL⁃10，inf⁃γ and TNF⁃α were significantly lower than those of the control group（P < 0.05）. In addition，the level of stress related hormones was lower than that of the control group（P < 0.05）and the recurrence rate of the observation group was significantly lower than that of the control group.The recurrent rash，Epstein Barr virus infection and higher blood pressure were observed Small plate，D⁃dimer and renal damage were risk factors for recurrence. Conclusion In the treatment of allergic purpura by using Anisodamine combined with montelukast，the inflammatory and oxidative stress reactions were significantly decreasedand the recurrence was low.

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