At present，chemotherapy，targeted therapy and endocrine therapy have constituted the corner⁃stone of non⁃surgical treatment of breast cancer. From the clinical treatment status，the overall cure rate of breast cancer has been significantly improved. However，there is still a lack of adequate treatment for patients with advanced metastatic breast cancer. The advent of cancer vaccine therapy promises to solve this clinical dilemma. Breast cancer vaccine is a new treatment，which can be roughly divided into two categories：preventive vaccine and thera⁃peutic vaccine. Vaccine therapy introduces tumor⁃associated antigens，which can induce the activation of the body′s immune system to precisely kill cancer cells. It may also reduce the risk of cancer recurrence because of the body′s long immune memory. However，the clinical research results of universal breast cancer vaccine have not shown significant therapeutic effect. Therefore，in order to improve the therapeutic effect of patients with advanced meta⁃static breast cancer，it is necessary to consider trying to combine universal breast cancer vaccine with existing chemotherapy，radiotherapy，targeted therapy and other means，or try to develop individualized neoantigen vaccine to benefit patients.This article aims to review the development prospect of breast cancer vaccine and provide refer⁃ence for the development of breast cancer vaccine with better therapeutic or preventive effect.