实用医学杂志 ›› 2022, Vol. 38 ›› Issue (11): 1390-1394.doi: 10.3969/j.issn.1006⁃5725.2022.11.016

• 临床研究 • 上一篇    下一篇

壳聚糖蜂胶联合自体富血小板血浆复合材料在骨科非急性感染性创面中的临床应用

邢涛1 张应拴2 钱朝良2 李向洲2 韩李霞2 杨博2 1    

  1. 甘肃省中医院(兰州 730050);2 甘肃中医药大学(兰州 730030)

  • 出版日期:2022-06-10 发布日期:2022-06-10
  • 通讯作者: 张应拴 E⁃mail:zyshuan1994@126.com
  • 基金资助:
    兰州市科技计划项目(编号:2018⁃4⁃69)

Clinical effect of chitosan propolis PRP composite on non ⁃ acute infectious wounds of orthopedic patients 

XING Tao*,ZHANG Yingshuan,QIAN Chaoliang,LI Xiangzhou,HAN Lixia,YANG Bo.   

  1. Gansu Hospital of Tradi⁃ tional Chinese Medicine,Lanzhou 730050,China

  • Online:2022-06-10 Published:2022-06-10
  • Contact: ZHANG Yingshuan E⁃mail:zyshuan1994@126.com

摘要:

目的 探讨壳聚糖蜂胶复合材料联合 PRP(自体富血小板血浆)在骨科非急性感染性创面 中的临床效果。方法 收集 2020 1 月至 2021 10 月,我院骨科收治的 60 例四肢非急性感染性创面患 者,数字随机法分为 A 组(壳聚糖蜂胶治疗组 20 例)、B 组(壳聚糖 PRP 治疗组 20 例)和 C 组(壳聚糖蜂胶 PRP 复合材料治疗组 20 例)三组,并评估治疗 3、6、9、12 d 后疼痛、生活质量评分,并对创面愈合时间、愈 合面积、治疗前后炎性指标进行比较分析。结果 治疗前后三组患者疼痛、生活质量评分均具有明显改 善(P < 0.05);治疗后 C 组愈合时间明显短于 A 组和 B 组(P < 0.05);治疗 9 d C 组愈合面积优于 A 组和 B 组(P < 0.05);治疗 12 d C 组患者 C 反应蛋白、白细胞计数改善率明显优于 A 组和 B 组(P < 0.05)。 结论 PRP 联合壳聚糖蜂胶复合材料在骨科非急性感染性创面中应用可有效抗菌,加快创面愈合,减轻 患者疼痛感和提高患者生活质量。

关键词:

壳聚糖, 蜂胶, PRP, 骨科, 非急性感染创面

Abstract:

Objective To investigate the clinical effect of PRP(autologous platelet⁃rich plasma)combined with chitosan probe composite on non⁃acute infectious wounds of orthopedic patients. Methods From September 2020 to July 2021,60 patients with non⁃acute infectious wounds on limbs admitted to the orthopedics department of our hospital were randomly divided by digital random method into groups A,B and C treated with chitosan propolis chitosan PRP and chitosan propolis PRP composite,respectively,20 in each. The scores of pain,anxiety and quality of life after 3,6,9 and 12 days of treatment were evaluated. The wound healing time,healing area and inflammatory indexes before and after treatment were compared and analyzed. Results The scores of pain,anxiety and quality of life in three groups were significantly improved after treatment(P < 0.05). The healing time of group C was significantly shorter than that of group A and group B(P < 0.05). After 6 days treatment,the healing area of group C was significantly larger than those of group A and group B(P < 0.05). After 12 days treatment,the improvement rate of C⁃reactive protein and white blood cell count in group C was significantly higher than those in group A and group B(P < 0.05). Conclusion PRP combined with chitosan propolis composite material can effectively fight against bacteria,accelerate wound healing,relieve pain and improve the quality of life in orthopedic patients with non⁃acute infectious wounds.

Key words:

chitosan, propolis, PRP, orthopedics, non?acute infection wound