关键词:

新型冠状病毒, Delta 变异毒株, 野生株, 临床特征

Abstract:

Objective To investigate the clinical characteristics and laboratory results of patients infected with the Delta variant of concern（VOC）vs a cohort of wild⁃type. Methods A total of 145 patients infected with Delta VOC in Guangzhou Eighth People′s Hospital Affiliated to Guangzhou Medical University from May to June， 2021 were retrospectively analyzed as a contrast of 278 patients infected with wild ⁃type strain from January to February，2020. The differences of general demographics，clinical symptoms，laboratory examinations，lung CT imaging results were analyzed. Results In the Delta VOC group，common type was majority and 13 patients（11%） were severe and critical types. In terms of time interval from early onset to severe manifestation，patients in the Delta VOC group were significantly shorter than that of the wild⁃type strain group（P ≤ 0.05）. The incidences of pharyngodynia and anosmia in the Delta VOC group were significantly greater than those in the wild ⁃type strain group（P ≤ 0.05）. The incidences of the lymphocyte count decline in the Delta VOC group were significantly greater than those in the wild⁃type strain group（P ≤ 0.05）. The first time CT mainly showed that the ground glass opacity and interstitial inflammation change in the Delta VOC group showed no significant difference compared with the wild⁃type group（all P > 0.05）. Conclusion Mild case was still the primary type for patients infected with Delta VOC，the rate of severe cases didn′t increase apparently，but the time interval from onset to severe manifestation was significantly lower than that of the wild⁃type strain group. There was little difference between the two groups on multiple organs or systems injury.

Key words:

SARS?COV?2, delta VOC, wild?type strain, clinical characteristics