实用医学杂志 ›› 2022, Vol. 38 ›› Issue (23): 2898-2902.doi: 10.3969/j.issn.1006⁃5725.2022.23.002

• 新型冠状病毒肺炎专栏 • 上一篇    下一篇

接种新型冠状病毒疫苗儿童新型冠状病毒肺炎病例临床特点 

田洪飞 吕铁锋 刘寿荣 丁莹 李舒欢 赵春 田力    

  1. 杭州市西溪医院(杭州市第六人民医院、浙江大学医学院附属杭州市西溪医院)(杭州310000)

  • 出版日期:2022-12-10 发布日期:2022-12-10
  • 通讯作者: 刘寿荣 E⁃mail:lsr85463990@126.com
  • 基金资助:
    杭州市科技计划引导项目(编号:20211231Y050)

Clinical features of COVID⁃19 infection in children vaccinated against novel coronavirus

TIAN Hongfei, LÜ Tiefeng,LIU Shourong,DING Ying,LI Shuhuan,ZHAO Chun,TIAN Li.   

  1. Hangzhou Xixi Hospital(Hangzhou Sixth People′s Hospital,Hangzhou Xixi Hospital,Zhejiang University School of Medicine),Hangzhou 310000,China

  • Online:2022-12-10 Published:2022-12-10
  • Contact: LIU Shourong E⁃mail:lsr85463990@126.com

摘要:

目的 探讨感染新型冠状病毒(SARS⁃CoV⁃2)的儿童,分析接种 SARS⁃CoV⁃2 疫苗与未接种 SARS⁃CoV⁃2 疫苗儿童临床特点的差异。方法 选取杭州市第六人民医院 2020 1 21 日至 2022 4 28 日收治的 14 岁以下儿童新冠病毒肺炎(COVID⁃19)病例 66 例为研究对象,根据是否接种新冠疫苗分两 组:接种疫苗组(n = 40),未接种疫苗组(n = 26),对两组临床特征、实验室检查资料、住院天数进行比较。结果 临床症状发生率在两组之间差异无统计学意义(P > 0.05);两组患儿均有白细胞、淋巴细胞、 中性粒细胞、嗜酸性粒细胞计数降低及血小板计数升高(两组均未见血小板计数降低病例),上述指标 降低比例及血小板计数升高比例差异无统计学意义(P > 0.05);两组患儿均有 AST、LDH、CK⁃MB 升高,其 中未接种疫苗组 LDH 升高比例较接种疫苗组高,两组比较差异有统计学意义(P < 0.05);两组间 AST CK⁃MB 升高比例差异无统计学意义(P > 0.05);接种疫苗组患儿平均住院天数(10.1 ± 5.5)d,未接种组患儿平均住院天数(16.4 ± 13.0)d,两组间差异有统计学意义(P < 0.01);接种疫苗组患儿 IgG 抗体滴度 147.7 ± 140.9)(AU/mL),未接种组患儿 IgG 抗体滴度(79.5 ± 114.1)(AU/mL),两组比较差异有统计学意 义(P < 0.05)。结论 本研究显示儿童感染 SARS⁃CoV⁃2,临床症状轻,较少出现重症及危重症,患儿大多 数有肝功能、心肌的炎性损伤,接种疫苗组可能机体炎性损伤更轻,新冠疫苗可能是减少儿童机体炎性损 伤和住院天数,尽快获得康复的关键。

关键词:

新型冠状病毒, 儿童, 疫苗 ,

Abstract:

Objective To investigate the clinical characteristics of children infected with coronavirus disease 2019(COVID⁃19)and to analyze the differences between children vaccinated against coronavirus vaccine and those not vaccinated. Methods Sixty⁃six COVID⁃19 cases(< 14⁃year⁃old)who were admitted to Hangzhou Sixth People′s Hospitalfrom January 21,2020 to April 28,2022 were selected and assigned to vaccinated group (n = 40)and unvaccinated group(n = 26)according to whether they had received vaccine or not. The clinical characteristics,laboratory data and average hospitalstays were compared between the two groups. Results There was no statistical significance in the incidence of clinical symptoms between the two groups(P > 0.05);the count of white blood cells,lymphocytes,neutrophils and eosinophils were decreased and the count of platelet was increased in both groups,and there was no statistical significance in the decrease rates of the above indicators and the increase rates of platelet counts(P > 0.05);AST,LDH and CK⁃MB were increasedin all the children between two groups,and the increase rate of LDH in the unvaccinated group was higher than that of the vaccinated group,with statistical significance(P < 0.05),and there was no statistical significance in the increased rates of AST and CK⁃ MB between two groups(P > 0.05);Statistical significance was found in average hospital stay(10.1 ± 5.5 vs. 16.4 ± 13.0 days,P < 0.01 and IgG antibody titer(147.7 ± 140.9 vs. 79.5 ± 114.1 AU/mL,P < 0.05)between the vacci⁃ nated and unvaccinated group. Conclusions This study showed that the clinical symptoms of children infected with COVID⁃19 were mostly mild,and severe and critical illnesses are less frequent. Most of the children had liver function damage and myocardium inflammation. The inflammatory damage of the children in the vaccinated groupwas milder. The covid⁃19 vaccine may be the key to reduce the inflammatory damage,shorten the hospitalization and fasten physical recovery in children.

Key words:

SARS?CoV?2, children, vaccine