实用医学杂志 ›› 2020, Vol. 36 ›› Issue (22): 3135-3139.doi: 10.3969/j.issn.1006⁃5725.2020.22.021

• 医学检查与临床诊断 • 上一篇    下一篇

基质金属蛋白酶⁃9及金属蛋白酶组织抑制剂1在呼吸道合胞病毒毛细支气管炎进展为哮喘中的意义

康平, 孙晓敏, 赵少聪, 冯一川, 李奕   

  1. 郑州大学附属儿童医院1呼吸科,2 普内科,3 检验科,4 过敏原治疗室(郑州450000)
  • 出版日期:2020-11-25 发布日期:2020-12-14
  • 通讯作者: 赵少聪E⁃mail:zhaomin_pds@163.com
  • 基金资助:
    2018 河南省医学科技攻关计划(联合共建项目)(编号:2018020681)

Significance of matrix metalloproteinase⁃9 and matrix metalloproteinase tissue inhibitor 1 in progression of respiratory syncytial virus bronchiolitis to asthma

KANG Ping,SUN Xiaomin,ZHAO Shaocong,FENG Yichuan,LI Yi   

  1. Respiratory Department,Children′ s Hospital Affiliated of Zhengzhou University,Zhengzhou 450000,China
  • Online:2020-11-25 Published:2020-12-14
  • Contact: ZHAO Shaocong E⁃mail:zhaomin_pds@163.com

摘要:

目的 探讨血清基质金属蛋白酶⁃9(MMP⁃9)及金属蛋白酶组织抑制剂1(TIMP⁃1)在呼吸道合胞病毒(RSV)毛细支气管炎中的意义。方法 检测毛细支气管炎患儿(RSV 组)及健康对照组血清MMP⁃9 和TIMP⁃1 的含量,根据随访结果将RSV 组分为非哮喘组和哮喘组。ROC 曲线及logistic 回归分析MMP⁃9、TIMP⁃1 和MMP⁃9/TIMP⁃1 在RSV 毛细支气管炎及其进展为哮喘中的诊断性能。结果 RSV 组MMP⁃9、TIMP⁃1 和MMP⁃9/TIMP⁃1 水平均显著高于对照组(P<0.05),其诊断RSV 毛细支气管炎的AUC 分别为0.942、0.579、0.827。哮喘组MMP⁃9 及MMP⁃9/TIMP⁃1 显著高于非哮喘组(P<0.05);MMP9、MMP⁃9/TIMP⁃1是RSV 毛细支气管炎向哮喘进展的独立危险因素(P<0.05)。结论 血清MMP⁃9、TIMP⁃1水平对RSV毛细支气管炎病情进展具有一定提示意义。

关键词: 呼吸道合胞病毒, 毛细支气管炎, 哮喘, 基质金属蛋白酶?9, 基质金属蛋白酶组织抑制剂1

Abstract:

Objective To investigate the significance of serum matrix metalloproteinase⁃9(MMP⁃9)andmatrix metalloproteinase tissue inhibitor 1(TIMP⁃1 in the development of respiratory syncytial virus(RSV)bronchiolitis to asthma. Methods The serum MMP⁃9 and TIMP⁃1 of RSV bronchiolitis children(RSV group)andhealth control were determined,and the RSV group were divided into non⁃asthmatic subgroup and asthma subgroupaccording to the follow⁃up results. ROC curve and logistic regression were used to analyze the performance ofMMP⁃9,TIMP⁃1 and MMP9/TIMP⁃1 in the diagnosis of RSV bronchiolitis and its progression to asthma. Results Compared with those in the control group,MMP⁃9,TIMP⁃1 and MMP9/TIMP⁃1 in the RSV group were significantlyincreased(P < 0.05). The area under the curve(AUC)of MMP⁃9,TIMP⁃1 and MMP9/TIMP⁃1 for the diagnosisof RSV bronchiolitis was 0.942,0.579,and 0.827,respectively. Compared with those in non⁃asthmatic group,MMP⁃9 and MMP9/TIMP⁃1 in asthma group were significantly increased(P < 0.05). MMP⁃9 and MMP⁃9/TIMP⁃1were independent risk factors in the development of RSV bronchiolitis to asthma(P < 0.05). Conclusion SerumMMP⁃9 and TIMP⁃1 have certain significance in RSV bronchiolitis and its progression to asthma.

Key words: respiratory syncytial virus, bronchiolitis, asthma, Matrix metalloproteinase?9, matrix metalloproteinase tissue inhibitor

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