关键词:

早产儿, 支气管肺发育不良, 危险因素

Abstract:

Objective To explore the risk factors of BPD in extremely premature and preterm infants with gestational age less than 32 weeks. Methods A total of 171 premature infants with gestational age < 32 weeks who were hospitalized in the neonatal intensive care unit of our hospital from January 1，2019 to April 30，2021 were selected and divided into BPD group and non⁃BPD group according to the clinical diagnosis. The general infor⁃ mation of children in the two groups at birth，the main diseases and treatment measures after admission，complica⁃ tions，and the general information of mother before delivery were analyzed retrospectively. Multivariate logistic regression was used to analyze the risk factors of BPD. Results The incidence of BPD in 171 children was 38.5% （66/171），including 34 males and 32 females. By univariate analysis，there were statistical significant differences between the two groups in birth weight，gestational age，multiple fetuses，5⁃minute Apgar score，rescue tracheal intubation in delivery room，first arterial blood gas after admission：PH，PaO2 and PaCO2，oxygen concentration at admission，number of blood transfusions during hospitalization，time to use antibiotics（days），re⁃intubation after admission，use of pulmonary surfactant（PS），use of invasive mechanical ventilation，invasive ventilation time ≥ 7 days，neonatal respiratory distress syndrome（RDS）and patent ductus arteriosus（PDA）（P < 0.05）. By multi⁃ variate Logistic regression analysis，gestational age（OR = 2.033，95%CI：1.161 ~ 3.559，P = 0.013），mechanical ventilation（OR = 0.165，95%CI：0.031 ~ 0.883，P = 0.035），and PaO2 at admission PaO（2 OR = 1.025，95%CI： 1.002 ~ 1.049，P = 0.033）were the independent risk factors for BPD in premature infants. Conclusion The occurrence of BPD is closely related to gestational age. The smaller the gestational age is，the higher the incidence of BPD. On the other hand，premature infants with low PaO2 at admission and receiving invasive mechanical venti⁃ lation are more likely to develop BPD.

Key words: premature,  , bronchopulmonary dysplasia,  , risk factors