实用医学杂志 ›› 2022, Vol. 38 ›› Issue (18): 2284-2288.doi: 10.3969/j.issn.1006⁃5725.2022.18.007

• 临床新进展 • 上一篇    下一篇

幽门螺杆菌毒力因子血型抗原结合黏附素在胃癌中的研究现状

 俞阳1王娜1王博方1李玉民12 陈昊12   

  1. 1 兰州大学第二医院(第二临床医学院)肿瘤外科(兰州 730030);2 兰州大学第二医院甘肃省消化系肿瘤重 点实验室(兰州 730030)

  • 出版日期:2022-09-25 发布日期:2022-09-25
  • 通讯作者: 陈昊 E⁃mail:ery_chenh@lzu.edu.cn;李玉民 E⁃ mail:liym@lzu.edu.cn

The Helicobacter pylori BabA in gastric cancer:Current research advances 

YU Yang*,WANG Na,WANG Bofang,LI Yumin,CHEN Hao.    

  1. Department of Tumor Surgery,Lanzhou University Second Hospital,the Second Clinical Medical College of Lanzhou University,Lanzhou 730030,China;*Key Laboratory of Digestive System Tumors of Gansu Province,Lanzhou University Second Hospital,Lanzhou 730030,China 

  • Online:2022-09-25 Published:2022-09-25
  • Contact: CHEN Hao E⁃mail:ery_chenh@lzu.edu.cn;LI Yumin E⁃mail:liym@lzu.edu.cn
  • Supported by:

    国家自然科学基金(编号:31770537,82160129);甘肃 省教育厅教育揭榜挂帅项目(编号:2021jyjbgs⁃02);甘肃省科技重大 专项(编号:20ZD7FA003⁃1);甘肃省重点人才项目(编号:2019RCXM020); 兰州市城关区科技计划项目(编号:2019RCCX0034)

摘要:

幽门螺杆菌(H.pylori)感染已成为当前公共卫生领域重要的问题之一,与多种胃肠道疾病的 发生发展相关,尤其是胃癌,已有大量证据证实了两者之间的确切关系。目前,对于 H.pylori 致病机制的 研究主要集中在 H.pylori 的毒力因子。血型抗原结合黏附素(blood group antigen⁃binding adhesion,BabA)作 为一种新识别的毒力因子,在 H.pylori 诱导胃癌发生发展中的作用逐渐获得关注。本文将对 BabA 的结构 功能、表达调控、促胃癌作用以及临床应用等方面进行全面综述,旨在为开发新型防治策略提供方向。

关键词:

胃肿瘤, 幽门螺杆菌, 血型抗原结合黏附素, LewisB, 危险因素

Abstract:

Infection of Helicobacter pyloriH.pylori)has become one of the intractable problems in the field of public health. It was identified asan association with many gastrointestinal diseases. Specially,its associa⁃ tion with gastric cancer that has been confirmed by substantial evidence.At present ,the studies that attend to explore the pathogenic mechanism of Hp mainly focus on the protein of virulence factor. As a newly identified virulence factor,the blood group antigen ⁃binding adhesion(BabA)has obtained a great attention on its roles for Hp to induce the occurrence and development of gastric cancer. This paper will comprehensively review the structure and function of BabA,its expression regulation,gastric cancer⁃promoting roles and clinical application,aiming to provide direction for developing new strategies in preventing and treating gastric cancer.

Key words:

stomach neoplasms, Helicobacter pylori, BabA, LewisB, risk factor