关键词:

血管内皮生长因子, 2型糖尿病, 视网膜微血管病变, 危险因素

Abstract:

Objective To investigate the predictive value of vascular endothelial growth factor（VEGF） level in patients with type 2 diabetes mellitus（T2DM）complicated with retinal microangiopathy. Methods A total of 146 patients with T2DM treated in our hospital from July 2018 to March 2021 were selected and were divided into DR group（n = 67）and non⁃DR group（n = 79）. Univariate and multivariate Cox regression analysis of the factors affecting T2DM patients with DR；The nomogram prediction model is constructed according to the independent influencing factors，and its prediction efficiency is evaluated. Results The course of T2DM in DR group was significantly longer than that in non ⁃DR group（P < 0.05）. In terms of biochemical indexes，FPG，HbA1c，GA， SCR，UA，bun，UACR and VEGF in DR group were significantly higher than those in non DR group（P < 0.05）， while ALB and RBC were significantly lower than those in non DR group（P < 0.05）. The course of T2DM， HbA1c，UA and VEGF were independent risk factors for DR in T2DM patients（P < 0.05），ALB and RBC were protective factors（P < 0.05）. The area under ROC curve（AUC）of the prediction model constructed according to risk factors was 0.874（95%CI：0.825 ~ 0.928，P < 0.001），which had high prediction value. Conclusion The level of VEGF was significantly increased in the serum of DR patients，which could be an independent risk factor for T2DM patients with DR and has a high predictive value for DR. 

Key words:

vascular endothelial growth factor, type 2 diabetes, diabetic retinopathy, risk factors