关键词:

结核病,  , 结核分枝杆菌,  , 亚单位疫苗,  , 抗原,  , 佐剂

Abstract:

Tuberculosis is still the main infectious disease that causes adult deaths worldwide and has been a global public health challenge for the past 25 years. At present，the only approved tuberculosis vaccine is BCG and there is still a long way to go to develop safer and more effective vaccine of tuberculosis. Recombinant subunit vaccines have clear components，high safety，can induce high⁃efficiency immune responses，and provide long⁃term immune protection effects. So they have good application prospects. This article reviewed the progress in the components，clinical research status，and application of the tuberculosis recombinant subunit vaccine.

Key words:

tuberculosis（TB）, Mycobacterium tuberculosis（M.tb）, subunit vaccine, antigen, adjuvant