实用医学杂志 ›› 2021, Vol. 37 ›› Issue (15): 1963-1966.doi: 10.3969/j.issn.1006⁃5725.2021.15.011

• 临床研究 • 上一篇    下一篇

胆囊癌组织星形胶质细胞上调基因1异常表达与临床病理及预后的关系

崔大鹏1, 张迎春2, 宋文丽3, 张鹏娟3, 张星月3, 刘振显2, 连晶晶4, 刘博5   

  1. 河北北方学院附属第一医院1 肝胆外科,2 普通外科,3 护理部 4 检验科,5 病理科(河北张家口075000)

  • 出版日期:2021-08-10 发布日期:2021-08-10
  • 基金资助:
    2019 年度河北省医学科学研究课题计划(编号:20190915)

The relationship between abnormal expression of astrocytes up⁃regulated gene 1 in gallbladder cancer tis⁃ sue and clinicopathology and prognosis 

CUI Dapeng,ZHANG Yingchun,SONG Wenli,ZHANG Pengjuan ZHANG Xingyue,LIU Zhenxian,LIAN Jingjing,LIU Bo.   

  1. Department of Hepatobiliary Surgery,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China

  • Online:2021-08-10 Published:2021-08-10

摘要:

目的 探讨胆囊癌组织星形胶质细胞上调基因 1(AEG⁃1)表达与临床病理及预后的关系。 方法 选取 2016 1 月至 2018 6 月收治的 128 例胆囊癌患者,均于术后进行癌组织 AEG⁃1 检测。随 访 2 年,记录生存时间。采用多因素COX回归分析胆囊癌患者预后影响因素,绘制Kaplan⁃Meier生存曲线。 结果 128 例患者癌组织 AEG⁃1 阳性率 71.87%。手术方式、肿瘤最大径、分化程度、TNM 分期、胆总管浸 润、淋巴结转移、AEG⁃1 表达是生存影响因素(P < 0.05)。AEG⁃1 阳性和阴性患者生存情况差异有统计学意义(P = 0.009)。结论 胆囊癌组织 AEG⁃1 表达与肿瘤最大径、病理分型、分化程度、TNM 分期、周围组织侵犯等有关,且AEG⁃1表达是预后影响因素。

关键词:

胆囊癌, 星形胶质细胞上调基因 1, 临床病理, 预后, 生存分析, 血管新生, 胞凋亡

Abstract:

Objective To investigate the relationship between the expression of astrocyte elevated gene⁃1 (AEG⁃1)in gallbladder cancer tissue and clinicopathology and prognosis. Methods A total of 128 patients with gallbladder cancer admitted from January 2016 to June 2018 were selected to take AEG⁃1 detection of cancer tissues after surgery. The survival time was recorded during a 2⁃year follow up. Multivariate COX regression was used to analyze the prognostic factors of patients with gallbladder cancer,while Kaplan ⁃Meier survival curve was drawn. Results The positive rate of AEG⁃1 in cancer tissues of 128 patients was 71.87%. Surgical method,maxi⁃ mum tumor diameter,degree of differentiation,TNM staging,common bile duct infiltration,lymph node metasta⁃ sis and AEG⁃1 expression were the survival factors(P < 0.05). There was statistically significant difference in sur⁃ vival between AEG⁃1 positive and negative patients(P = 0.009). Conclusion The expression of AEG⁃1 in gall⁃ bladder cancer tissue is related to the maximum diameter of the tumor,pathological type,degree of differentiation TNM stage,surrounding tissue invasion,etc.,and the expression of AEG⁃1 is a prognostic factor.

Key words:

gallbladder carcinoma, astrocyte up ? regulated gene 1, clinicopathology, prognosis, survival analysis, angiogenesis, apoptosis