实用医学杂志 ›› 2021, Vol. 37 ›› Issue (10): 1342-1345.doi: 10.3969/j.issn.1006⁃5725.2021.10.022

• 医学检查与临床诊断 • 上一篇    下一篇

磁敏感加权成像对针刺治疗帕金森病黑质致密带改变的评价

魏易琼, 赖丽莎, 薛丹,成秋生   

  1.  广州市第一人民医院1 神经内科,2 影像科,3 中医科(广州 510180)

  • 出版日期:2021-05-25 发布日期:2021-05-25
  • 基金资助:
    广州市卫生健康科技项目(编号:20202A011002);广州市科技局项目(编号:201904010427)

Evaluation of magnetic susceptibility weighted imaging on the changes of substantia nigra dense zone in Parkinson′s disease treated with acupuncture 

WEI Yiqiong,LAI Lisha,XUE Dan,CHENG Qiusheng.    

  1. De⁃partment of Neurology,Guangzhou First People′s Hospital,Guangzhou 510180,China  

  • Online:2021-05-25 Published:2021-05-25

摘要:

目的 应用磁敏感加权成像(SWI)测量针刺治疗帕金森病患者的黑质致密带(SNc)变化,无创性地评价针刺治疗帕金森病的疗效。方法 选择 2020 5-12 月在我院行针刺治疗的 50 例帕金森病患 者,治疗 3 个疗程后根据其治疗效果不同分为治愈组、缓解组和无效组。所有患者在治疗前、治疗 3 个疗 程后均进行 MRI 检查,采用 SWI 序列扫描,测量其 SNc 宽度、中脑直径比值、SN 面积,比较各组检查结果。 结果 三组针刺治疗前的 SNc 宽度、SN 面积、中脑直径、SNc/中脑直径比值对比差异无统计学意义(P > 0.05)。治疗 3 个疗程后,治愈组、缓解组的 SNc 宽度、SN 面积、中脑直径、SNc/中脑直径比值显著低于治疗前(P < 0.05),而无效组治疗前后的 SNc 宽度、SN 面积、中脑直径、SNc/中脑直径比值比较差异无统计学意 义(P > 0.05)。治疗后治愈组的 SNc 宽度、SN 面积、中脑直径、SNc/中脑直径比值明显低于缓解组和无效 组(P < 0.05)。结论 磁敏感加权成像检查可清楚显示帕金森病患者黑质致密带大小变化,其应用于针 刺治疗帕金森患者治疗效果判断中具有较高的价值。

关键词:

帕金森病, 黑质致密带, 磁敏感加权成像, 针刺治疗

Abstract:

Objective To evaluate the therapeutic effect of acupuncture on Parkinson′s disease by measur⁃ ing the changes of substantia nigra dense zone(SNC)with susceptibility weighted imaging(SWI). Methods 50 cases of patients with Parkinson′s disease who were treated with acupuncture in our hospital from May 2020 to December 2020 were selected. After 3 months of treatment,they were divided into cure group,remission group and ineffective group according to their therapeutic effects. All patients underwent MRI examination before and after 3 courses of treatment. SWI sequence scanning was used to measure the SNC width,midbrain diameter ratio and Sn area. Results There were no significant differences in SNC width,Sn area,midbrain diameter and SNC/ midbrain diameter ratio among the three groups before acupuncture treatment(P > 0.05). After 3 courses of treat⁃ ment,the SNC width,Sn area,midbrain diameter and SNC/midbrain diameter ratio of the cured group and remis⁃ sion group were significantly lower than those before treatment(P < 0.05),while there were no significant differ⁃ ences in SNC width,SN area,midbrain diameter and SNC/midbrain diameter ratio of the ineffective group before and after treatment(P > 0.05). After treatment,the SNC width,SN area,midbrain diameter and SNC/midbrain diameter ratio of the cured group were significantly lower than those of the remission group and the ineffective group (P < 0.05). Conclusion Susceptibility weighted imaging can clearly show the size change of substantia nigra dense zone in patients with Parkinson′s disease,and it has high value in judging the therapeutic effect of acupunc⁃ ture in patients with Parkinson′s disease. 

Key words:

Parkinson′ s disease, dense zone of substantia nigra, susceptibility weighted imaging, acupuncture treatment