实用医学杂志 ›› 2021, Vol. 37 ›› Issue (6): 773-777.doi: 10.3969/j.issn.1006⁃5725.2021.06.017

• 临床研究 • 上一篇    下一篇

原发性膜性肾病复发的多因素分析

岑雅伶, 杨佳青, 张丽娥, 甘瑞静, 杨洁, 黎海娟,王明军3   

  1. 广西医科大学1 第一临床医学院,2 公共卫生学院(南宁 530021);3 广西医科大学第一附属医院肾内科(南宁 530021)

  • 出版日期:2021-03-25 发布日期:2021-03-25
  • 通讯作者: 王明军 E⁃mail:wmjwyy2002@163.com
  • 基金资助:
    广西自然科学基金项目(编号:2018GXNS⁃FAA050061)

Multivariate analysis of recurrence of primary membranous nephropathy

CEN Yaling*,YANG Jiaqing ZHANG Li′e GAN Ruijing,YANG Jie,LI Haijuan,WANG Mingjun   

  1. The First School of Clinical Medicine Guangxi Medical University,Nanning 530021,China

  • Online:2021-03-25 Published:2021-03-25
  • Contact: WANG Mingjun E⁃mail:wmjwyy2002@163.com

摘要:

目的 研究影响原发性膜性肾病(primary membranous nephropathy,PMN)治疗后复发的危险因素,以期寻找出初治的 PMN 患者有预后预测意义的指标,能够早期发现高危因素的患者,减少PMN 患者的复发,降低进展至终末期肾病的可能性。方法 选取 2012 1 月至 2020 5 月在我院经肾穿病理活检确诊的初治的 PMN 患者作为研究对象,按照疗效分为复发组和非复发组,分析和比较复发组和非复发组的相关临床资料。结果 PMN 患者复发多因素 Cox 回归分析结果显示,高血压、高尿酸是PMN 复发的独立危险因素。结论 膜性肾病复发的主要危险因素为高血压、高尿酸血症,多发生在药物减量、停药和感染的情况下。

关键词:

Abstract:

Objective To study the risk factors of recurrence of primary membranous nephropathy (PMN),and to reduce the possibility of progression to end⁃stage renal disease. Method PMN patients diagnosed by renal biopsy in our hospital from January 2012 to May 2020 were selected as study subjects,and were divided into recurrent group and non⁃recurrent group. The clinical data of the two groups were analyzed and compared. Results Multivariate COX regression analysis showed that hypertension and high uric acid were independent risk factors for the recurrence of PMN. Conclusion The main risk factors of the recurrence of PMN are hypertension and hyperuricemia. Relapses occur in the context of drug reduction,withdrawal,and infection.

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