关键词: 结直肠癌, DCAMKL?1, p53, 免疫组织化学

Abstract:

Objective To investigate the correlation of DCAMKL⁃1 and p53 expression with pathologicalcharacteristics of colorectal carcinoma（CRC）and patients′ prognosis. Methods DCAMKL⁃1 and p53 expressionin 126 cases CRCs and ANM. The correlations of their expression with patients′ pathological characteristics andprognosis were evaluated based on Spearman correlation analysis and survival analysis. Results In CRCs，the pos⁃itive rate of DCAMKL⁃1 was 71.4%（90/126），which was significantly higher than that of ANMs（P < 0.05）.There was no correlation between DCAMKL⁃1 expression and patients′ age，gender，clinical stage，lymph nodemetastases（P > 0.05）. The distributions of CRCs and ANMs were 25.4%（32/126），14.3%（18/126），60.3%（76/126）and 92.1%（116/126），7.9%（10/126），0（0/126）in the p53⁃no，mild and strong expression groups，respectively. In CRCs，the strong positive rate of p53 was 60.3%（76/126），which was significantly higher thanthat of ANMs（P <0.05）. The expression of p53 was associated with clinical stage（χ2 = 3.925，P＜0.05）andlymph node metastasis（χ2 = 7.292，P＜0.05）. The CRCs with p53⁃no and p53 strong expression are prone tometastasize（P＜0.05）. Multivariate analysis revealed that clinical stage was independent prognostic factors of CRCpatients（P < 0.05）. Conclusions DCAMKL⁃1 and p53 are closely related to the occurrence of CRC. p53 isrelated to the clinical stage and lymph node metastasis. Clinical stageis independent prognostic indicator of CRC.

Key words: colorectal carcinoma, DCAMKL?1, p53, immunohistochemistry