关键词:

肝爽颗粒, 恩替卡韦, 乙型肝炎肝硬化, D?二聚体, 高凝状态, 门静脉血栓

Abstract:

Objective To investigate the effect of Ganshuang granule combined with entecavir on plasma D⁃dimer level in patients with hepatitis B related cirrhosis. Methods Patients with hepatitis B related cirrhosis with elevated D ⁃ dimer were randomly divided into two groups：The observation group （191 cases） took the Ganshuang granule 0.3 grams/time，3 times/day，Entecavir 0.5 mg/time，1 time/day of 48 weeks. 165 cases in the control group were treated with entecavir 0.5 mg/time，once a day for 48 weeks. The changes of plasma D⁃dimer levels at baseline，6 months and 12 months of treatment were compared by repeated measurement analysis of variance. Results the plasma D⁃dimer of the two groups was 3.44 ± 1.33 mg/L and 3.59 ± 1.30 mg/L at baseline （P > 0.05）. Repeated measurement ANOVA showed that the main effect between groups was significant，F = 58.953，P < 0.001，partial η2 = 0.143；The main effect of time was significant，F = 545.167，P < 0.001，partial η2 = 0.606；The interaction effect between time and group was significant，F = 10.117，P < 0.001，partial η2 = 0.028. At 6 and 12 months after treatment，the decrease of plasma D⁃dimer level in the observation group was higher than that in the control group（P < 0.05）；The level of plasma D⁃dimer decreased at baseline，6 months and 12 months in each group（P < 0.05）. There were significant differences in the incidence of portal vein thrombosis， ascites and gastrointestinal bleeding between the two groups（P < 0.05）. Conclusion Compared with entecavir alone，Ganshuang granule combined with entecavir could significantly reduce the level of plasma D⁃dimer in patients with hepatitis B cirrhosis，and the effect was more obvious with the extension of time，which could effectively prevent the formation of portal vein thrombosis.

Key words:

ganshuang granule, entecavir, Hepatitis B related cirrhosis, D?dimer, hypercoagula? ble state, portal vein thrombosis