食管鳞癌中TOP2A蛋白的表达与临床预后的关系

doi:10.3969/j.issn.1006-5725.2019.16.020

实用医学杂志 ›› 2019, Vol. 35 ›› Issue (16): 2607-2610.doi: 10.3969/j.issn.1006-5725.2019.16.020

食管鳞癌中TOP2A蛋白的表达与临床预后的关系

李宾, 王忠民, 陈志军, 董成来, 曹克鑫, 甘绍印, 陶义鹏

新乡医学院第一附属医院胸外一科（河南新乡 453100）

收稿日期:2019-04-29 出版日期:2019-08-27 发布日期:2019-08-27
通讯作者: 王忠民 E-mail：13703430698@163.com
基金资助:
河南省卫生和计划生育委员会项目（编号：2018020366）

Correlation studies between TOP2A expression and prognosis in esophageal carcinoma

LI Bin, WANG Zhongmin, CHEN Zhijun, DONG Chenglai, CAO Kexin, GAN Shaoyin, TAO Yipeng

Department of Chest Surgery, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, China

Received:2019-04-29 Online:2019-08-27 Published:2019-08-27
Contact: WANG Zhongmin E-mail： 13703430698@163.com

摘要/Abstract

摘要： 目的通过检测食管癌组织中TOP2A蛋白的表达,探讨其与食管癌患者预后之间的关系。方法采用免疫组织化学方法研究TOP2A蛋白在98例食管癌标本中的表达水平,并分析其临床病理特征与食管鳞癌患者5年生存率之间的关系。结果 TOP2A蛋白在98例食管癌组织及55例癌旁组织中的阳性率分别为47.9%和23.6%;采用Kaplan-Meie（K-M）法进行单因素分析并计算生存率,COX风险比例模型进行多因素分析,结果显示分化程度、淋巴结转移、临床分期及TOP2A表达是临床预后的独立危险因素,TOP2A表达阳性患者的5年生存率为19%,而TOP2A表达阴性患者的5年生存率为25%。结论 TOP2A在食管鳞癌中的表达增高,且与食管癌的发生发展、侵袭转移关系密切,TOP2A表达、分化程度、淋巴结转移及临床分期是影响食管鳞癌患者远期预后的主要因素。

关键词: 食管癌, TOP2A, 免疫组织化学, 5年生存率

Abstract: Objective Investigation of the correlation between expression of TOP2A and prognosis in human esophageal carcinoma by immunohistochemical staining analysis with the aim of evaluating the feasibility for TOP2A as an prognosis marker of esophageal carcinoma. Methods The expression levels of TOP2A in 98 samples of patients with esophageal carcinoma were detected using immunohistochemical method and its correlation with clinical pathological characteristics and prognosis was analyzed. Results The positive rates of TOP2A in 98 cases of esophageal carcinoma tissue and 55 cases of tissue adjacent to carcinoma were 47.9% and 23.6% respectively. The Kaplan-Meier（K-M） method was applied for univariate analysis and COX regression model was applied for multivariate analysis. The yield Results showed that TOP2A expression, differentiation degree, lymph node metastasis and clinical stage were independent factors of prognosis（P < 0.05）. The five-year survival rate of patients with TOP2A positive was 19%; The five-year survival rate of patients with TOP2A negative was 25%. Conclusion The elevated TOP2A expression level in esophageal carcinoma has a potential correlation with invasion of the esophageal carcinoma, development and transfer. TOP2A expression, differentiation degree, lymph node metastasis and clinical stage are the main factors that contributes to the prognosis of patients with esophageal carcinoma.

Key words: esophageal carcinoma, TOP2A, immunohistochemical, 5-year survival rate

李宾, 王忠民, 陈志军, 董成来, 曹克鑫, 甘绍印, 陶义鹏. 食管鳞癌中TOP2A蛋白的表达与临床预后的关系[J]. 实用医学杂志, 2019, 35(16): 2607-2610.

LI Bin, WANG Zhongmin, CHEN Zhijun, DONG Chenglai, CAO Kexin, GAN Shaoyin, TAO Yipeng. Correlation studies between TOP2A expression and prognosis in esophageal carcinoma[J]. The Journal of Practical Medicine, 2019, 35(16): 2607-2610.

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食管鳞癌中TOP2A蛋白的表达与临床预后的关系

Correlation studies between TOP2A expression and prognosis in esophageal carcinoma

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