Kaposi′s sarcoma（KS）is an aggressive lymphoangioproliferative tumor. Its occurrence is closelyrelated to the infection of endothelial cells by Kaposi sarcoma associated herpesvirus （KSHV）. KS caused byKSHV is a common concurrent malignant tumor of AIDS，which is more common in Mediterranean and Africa，with high mortality. The treatment of Kaposi sarcoma is one of the difficult problems in clinical practice. In recentyears，KS has achieved a breakthrough. Especially after the advent of CART ，the incidence rate of KS hasdecreased significantly，and the prognosis of patients has improved significantly. This article reviews the progress ofclinical treatment of Kaposi′s sarcoma.