Oral squamous cell carcinoma（OSCC）is the most common oral cancer. More than 300，000new cases are diagnosed every year in the world，most patients are in middle or advanced stage and have a fairlypoor prognosis. So far，biopsy are still the gold standard for diagnosis of oral cancer，butthere are still many limita⁃tions in its clinical application for its invasiveness and surgical complications. In recent years，liquid biopsy hasattracted extensive attention in clinical practice due to its unique simplicity，non⁃invasiveness and repeatability，showing a broad application prospect.In this review，we summarize the new research findings among miRNA in oralsquamous cell carcinoma liquid biopsy