Objective To investigate the prevalence and short⁃term prognosis of patients with acute kid⁃ ney injury（AKI），and to explorethe risk factors of poor prognosis. Methods We conducted a single center study. Clinical data of AKI patients from January 1，2015 to December 31，2018 were analyzed retrospectively. And the follow⁃up was implemented from the confirmation of AKI to the discharge. Results A total of 2 807 patients with AKI were enrolled in the study. Of the total，7.8% of the patients died；20.4% had no recovery of renal function； 35.9% partial recovery，and 22.1% complete recovery.The rate of AKI stage 1，2，and 3 was 27.0%，21.9%，and 51.1%，respectively. The higher the stage，the higher the fatality rate. Multivariate regression analysis showed that advanced age，ICU admission，cardiac insufficiency，MODS，and shock，acidosis，and non ⁃nephrological inter⁃ ventions were risk factors for all⁃cause death from AKI（all P < 0.05）. In addition，smoking，proteinuria，and respiratory failure are risk factors for the failure of renal function recovery in AKI（all P < 0.05）. Survival analysis showed that patients with nephrology intervention had a lower risk of renal failure than those without（P < 0.001）. Conclusion AKI leads tohigher mortality and lower renal function recovery rate. Important factors affecting AKI short⁃term prognosis include age，ICU admission，cardiac insufficiency，MODS，shock，acidosis，and with nephrology intervention or not. Nnephrology intervention helps improve the poor prognosis.