Receptor for advanced glycation end products（RAGE）belongs to a cell surface immunoglobulin superfamily molecule，which is expressed on a variety of cell surfaces，such as monocyte macrophages，vascular endothelial cells，smooth muscle cells and neuron cells. At present，the pathogenesis of Kawasaki disease（KD）is not clear，but in recent years，it has been found that expression of receptor for advanced glycation end products on the surface of circulating endothelial cells is upregulated in KD. In vivo，a variety of ligands can bind to RAGE， which mediates the release of inflammatory factors and activation of inflammatory pathways，thus affecting the pathogenesis of KD. Blocking RAGE pathway may interfere with the progression of coronary artery lesions in Kawa⁃ saki disease，and it is expected to provide a new targeted treatment for KD. This article reviews the research prog⁃ ress of RAGE pathway in KD and the strategy of blocking RAGE.