Spinal cord injury（SCI）is a highly disabling disease，which will seriously reduce the patients′mobility，disability adjusted life expectancy，cause huge losses to patients′ families and society. Even the discussionabout whether glial scarsexerteda positive or negative effect not stopped，previous studies showed that glial scars had agreat impact on SCI. In any case，mastering the method of reducing glial scar formation after SCI would provide achoice for further treatment of SCI，helping neuron regeneration and restoring movement and sensation. Therefore，we reviewed the methods of reducing glial scar formation after SCI in the past three years. In future research，researchers could work harder to achieve more precise，effective，accessible，and safe applications based on exist⁃ing research. Carrying out combination therapy would reduce irritation and risk. It would also promote more safe andeffective methods into the clinic and thus relieve the pain of patients with SCI.