Long non⁃coding RNA（lncRNA）is a multifunctional non⁃coding RNA involving in the regula⁃ tion of the development of a variety of tumors. GSK⁃3β is a serine and threonine kinase that plays an important role in tumor regulation through Wnt/β⁃catenin，PI3K/Akt，Notch，NF⁃κB and Hedgehog signaling pathways. In recent years，increasing studies have shown that the interactions between lncRNA and GSK⁃3β related signaling pathways play an important role in various tumors and are closely related to patient prognosis. In this paper，the roles of lncRNA and GSK ⁃ 3β related signaling pathways in various tumors are reviewed，so as to provide reference and thinking for clinical treatment and future research.