Objective To explore the clinical value of 3D printing technology in infantile craniostenosis surgery. Methods A total of 60 cases with infantile craniostenosis were collected and randomly divided into 3D printing group and control group with 30 cases in each group. In 3D printing group，3D printing technology was applied to reconstruct the skull model before operation，assist the frontal orbital girdle to move forward or retracted， and guide the surgical treatment of stenosis. Routine imaging examination was performed in the control group before the operation，and the operation was completed by the same operator. Surgical efficacy of the two groups was com⁃ pared. Results At the 3⁃month follow⁃up，the cephalic index（CI）of brachycephaly in the 3D printing group was （80.70 ± 1.10）and that in the control group was（89.30 ± 4.50）. The CI of scaphoid head in the 3D printing group was（78.30 ± 1.40）and that in the control group was（69.00 ± 4.20）. The anial vault asymmetry index（CVAI）in the 3D printing group was（1.60 ± 0.80）%，and that in the control group was（5.60±1.00）% . All the differences were statistically significant. Conclusion 3D printing⁃assisted frontal orbital girdle advancement or retraction tech⁃ nology in the operation of craniotomy can significantly improve the surgical treatment of various infantile cranioste⁃ nosis，and its effect is better than that of traditional surgery. It is worthy of clinical promotion.