Objective To study the clinical prognosis and pathological characteristics of patients with soft tissue tumors and bone tumors in the foot and ankle. Methods We selected 120 patients with foot and ankle soft tissue tumors and bone tumors admitted to our hospital，and analyzed the clinical pathological characteristics of the subjects and related factors affecting clinical prognosis. Results 69 cases were followed up after operation，50 cases of soft tissue malignant tumors，19 cases of bone malignant tumors. The 1⁃year survival rate of patients with bone malignant tumors was 75.36%，which was significantly higher than the 3⁃year of 55.07% and 5⁃year of 55.07%. Univariate analysis found the 5⁃year survival rate of 69 patients with foot and ankle malignant tumors was affected by adjuvant treatment，functional status and tumor size（P < 0.05），but gender，age，surgical method，tissue type， and location of tumor had no significant impact on the prognosis of patients（P > 0.05）；Multivariate analysis found that tumor size and functional status were independent risk factors affecting the survival rate of 69 patients with foot and ankle malignant tumors（HR = 7.251，6.194，P = 0.005）. Conclusion Benign soft tissue tumors of the foot and ankle are mostly hemangioma，while malignant tumors are mostly synovial sarcoma；tumor size and functional status are the main factors for the poor prognosis of patients with malignant tumors of the foot and ankle ，and patients with malignant tumors > 5 cm have a worse clinical prognosis.