Objective  This study aimed to reveal the clinical features of cases，and provide evidence andsupport for the active treatment of neonates with homologous Echovirus type 11（ECHO11）infection under modernmedical conditions. Methods  Clinical features and treatment experience of ECHO11⁃infected newborns trans⁃ferred from the same ward of a subordinate hospital to the neonatal intensive care unit of Guangzhou Women andChildren′s Medical Center in June 2019 were recorded. Results  The age related to infection onset is 1 ~ 16 d.The primary symptoms related to viral infection were vomiting（50%）and fever（50%）. Thrombocytopenia andautoimmune hemolytic disease（100%）appeared in the early stage of the disease. After plasmapheresis，glutamic⁃pyruvic transaminase level，total bilirubin level，and thrombin time were decreased significantly. Conclusions This study showed that all cases had thrombocytopenia and autoimmune hemolytic disease，and early repeated useof blood purification treatment might improve the prognosis. The autoimmune response of premature infants may bethe reasons for the rapid progression of severe cases，which need immediate attention.