Objective To investigate medical staff′s knowledge，attitude and practice toward post⁃stroke cognitive impairment and analyze its influencing factors. This will reflect the status，and serves as a reference for training needs among the staff with a view to facilitate early screening and prompt intervention for cognitive impair⁃ ment among stroke patients. Methods From April 2020 to May 2020，used general information questionnaire and self ⁃ designed medical staff′ s Knowledge，Attitude，Behavior questionnaire to post ⁃ stroke cognitive impairment based on KAP model to investigate 798 medical staff from 2 tertiary hospitals in Guangzhou. Results A total of 780（97.7%）valid questionnaires were collected，the participants′ average scores of knowledge，attitude，and practice related to cognitive impairment after stroke are（50.95 ± 12.994），（49.95 ± 7.687）and（49.19 ± 13.292） respectively. Results of multiple factor analysis showed that occupation，work department，occupational satisfac⁃ tion，training experience and education need are the main influencing factors of KAP of post ⁃stroke cognitive impairment（P < 0.01）. Conclusions The medical staff had a moderate level of knowledge and practice toward cognitive impairment after stroke，their attitude was positive. To ensure good prognosis of post⁃stroke cognitive impairment，early diagnosis and immediate rehabilitation are strongly recommended . However，training needs of medical staff should be prioritized to bridge their knowledge gap in assessment and management of cognitive impair⁃ ment among stroke patients.