Objective To unveil the prognostic effect of myocardial injury markers and NT⁃proBNP on patients aged ≥75 years with coronavirus disease⁃19（COVID⁃19）.Methods A total of 141 consecutive patients aged ≥75 years who were admitted to the hospital between 12th and 19th February 2020. In⁃hospital death，clinical characteristics and myocardial injury markers and NT ⁃ proBNP on admission were obtained from medical records. The association of myocardial markers evaluated by LDH，CK，CK ⁃MB，AST，ALT，hs ⁃TnI，and NT ⁃ proBNP were collected. Results 18（12.8%）patients died，including 11（61.1%）male and 7（38.9%）female. Patients with elevated level of LDH，hs⁃TnI，and NT⁃proBNP had significantly higher risk of death than those in discharged group（P < 0.05）. ROC curve analysis showed that the area under curves of NT⁃proBNP was the highest（0.94）， followed by hs⁃TnI（0.88）. When the cutoff value of NT⁃proBNP was 1 025 ng/L，the positive predictive value was 94.40% ，the negative predictive value was 89.40%. Conclusions Myocardial injury and elevated NT ⁃proBNP levels are common in elderly patients with COVID⁃19，